Exposure of Mycobacterium tuberculosis to human alveolar lining fluid shows temporal and strain-specific adaptation to the lung environment
A. A. Guardia, A. G. Vilanova, A. M. Schami, A. M. Olmo-Fontanez, A. Hicks, J. Peters, D. J. Maselli, M. D. Wewers, Y. Wang, J. B. Torrelles
This study exposes M.tb strains to human alveolar lining fluid and finds strain-specific and time-dependent gene expression changes, particularly in lipid metabolism and cholesterol degradation.
bioRxiv · Sep 27, 2023 · PreprintMicrobiology