J. Peters

Exposure of Mycobacterium tuberculosis to human alveolar lining fluid shows temporal and strain-specific adaptation to the lung environment

This study exposes M.tb strains to human alveolar lining fluid and finds strain-specific and time-dependent gene expression changes, particularly in lipid metabolism and cholesterol degradation.

Fatty acid synthesis knockdown promotes biofilm wrinkling and inhibits sporulation in Bacillus subtilis

This study uses CRISPRi to knockdown essential genes in Bacillus subtilis and finds that fatty acid synthesis knockdown increases biofilm wrinkling and inhibits sporulation.

Unravelling the mechanisms of adaptation to high pressure in proteins

This study identifies molecular mechanisms of high pressure adaptation in proteins through neutron scattering analysis of orthologous proteins.

High temperature molecular motions within a model protomembrane architecture

This study examines molecular motions in model protomembranes at varying temperatures to understand their structural dynamics and flexibility.

The dynamical Matryoshka model: 2. Modeling of local lipid dynamics at the sub-nanosecond timescale in phospholipid membranes

The paper applies the Matryoshka model to study lipid dynamics in DMPC and DMPG membranes across different temperatures and instruments, showing reliable agreement with experimental data.

The dynamical Matryoshka model: 3. Diffusive nature of the atomic motions contained in a new dynamical model for deciphering local lipid dynamics

The paper analyzes QENS spectra using the Matryoshka model to characterize atomic motion dynamics in lipid bilayers, confirming model parameters through independent analysis.

A Marmoset Model for Mycobacterium avium Complex Pulmonary Disease

This study infects marmosets with M. intracellulare to model M. avium complex pulmonary disease, showing infection, immune response, and radiographic changes similar to human disease.

The dynamical Matryoshka model: 1. Incoherent neutron scattering functions for lipid dynamics in bilayers

This paper develops a theoretical framework to model lipid dynamics in bilayers using the dynamical Matryoshka model, which accurately describes experimental QENS data and extracts dynamical parameters.

Human alveolar lining fluid from the elderly promotes Mycobacterium tuberculosis growth in alveolar epithelial cells and bacterial translocation into the cytosol

Testing hypotheses of marsupial brain size variation using phylogenetic multiple imputations and a Bayesian comparative framework

This study uses Bayesian phylogenetic analysis to test brain size variation in marsupials, finding litter size as the only significant predictor.

Demogenomic modeling of the timing and the processesof early European farmers differentiation

This study uses demogenomic modeling to show early European farmers arose from post-LGM mixing of Near Eastern and Western hunter-gatherer populations and experienced extreme genetic drift during westward expansion.

Characterization of gene repression by designed transcription activator-like effector dimer proteins

The paper quantitatively characterizes gene repression in E. coli using designed TALED proteins and compares them to natural lac repressor loops.

Expression of a transcript encoding for cytosolic renin in the diseased human heart

The paper investigates renin transcript expression in human heart disease biopsies, finding cytosolic renin-b expression but not secretory renin-a or renin-c.

Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression

This study uses transcriptome sequencing and multiplex imaging to show that monocytic cells drive prostate cancer progression and immune modulation.

Modulating pathogenesis with Mobile-CRISPRi

The paper demonstrates the use of Mobile-CRISPRi to knock down virulence life-style genes in a murine infection model, showing reduced virulence in mice.

Ancient Yersinia pestis genomes from across Western Europe reveal early diversification during the First Pandemic (541-750)

This study reconstructs six new Yersinia pestis genomes from the First Pandemic (541-750) and identifies genetic diversity and potential convergent evolution with later pandemics.

Taming the Late Quaternary phylogeography of the Eurasiatic wild ass through ancient and modern DNA

This study uses ancient and modern DNA to resolve the phylogeography of the Eurasiatic wild ass, identifying nine clades and clarifying the evolutionary history and gene flow between populations.