Author

A. MacFadden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Approach:biophysical modeling· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:virus· 2

Frequent Co-Authors

J. S. Kieft· 4 shared M. E. Sherlock· 2 shared A. Glasgow· 1 shared A. L. Franklin· 1 shared A.-L. Steckelberg· 1 shared C. J. Langeberg· 1 shared D. C. Pineda Rodriguez· 1 shared E. G. Chapman· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiochemistry

J. S. Kieft

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1

S. F. Maurina, J. P. O'Sullivan, G. Sharma, D. C. Pineda Rodriguez, A. MacFadden, F. Cendali, M. A. Henen, J. S. Kieft, A. Glasgow, A.-L. Steckelberg

This paper identifies conserved ribosome-binding mechanisms in β-coronavirus Nsp1 proteins and shows how a cis-acting RNA element modulates Nsp1 function.

bioRxiv · Jun 7, 2023 · PreprintBiochemistry

An Expanded Class of Histidine-Accepting Viral tRNA-like Structures

C. J. Langeberg, M. E. Sherlock, A. MacFadden, J. S. Kieft

The paper identifies new histidine-accepting tRNA-like structures in viral RNA genomes, expands their known diversity, and validates their structural and functional properties.

bioRxiv · Dec 2, 2020Biochemistry

Cryo-EM of a viral RNA and RNA-protein complex reveals how structural dynamics and novel tRNA mimicry combine to hijack host machinery

S. Bonilla, M. Sherlock, A. MacFadden, J. S. Kieft

The paper uses cryo-EM to visualize a viral RNA mimic bound to host enzyme, revealing structural dynamics and noncanonical interactions that enable viral hijacking of host machinery.

bioRxiv · Sep 18, 2020 · PreprintBiophysics

Engineering degradation-resistant messenger RNAs in yeast

A. L. Franklin, A. Macfadden, J. G. Kieft, J. Hesselberth, E. G. Chapman

This study shows that viral RNA structures can protect mRNA from degradation in yeast, increasing protein expression by 30-fold.

bioRxiv · Jun 25, 2020 · PreprintBiochemistry

Structural Diversity and Phylogenetic Distribution of Valyl tRNA-like Structures in Viruses

M. E. Sherlock, E. W. Hartwick, A. MacFadden, J. S. Kieft

The paper investigates the structural diversity and phylogenetic distribution of valyl tRNA-like structures in viruses, identifying structural heterogeneity and cases of anticodon switching.

bioRxiv · Jun 19, 2020Biochemistry