Author

A.-L. Steckelberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2 Approach:comparative / phylogenetic analysis· 1 Organism:human· 1 Organism:plant (other)· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. S. Kieft· 4 shared B. M. Akiyama· 2 shared D. A. Costantino· 2 shared J. C. Nix· 2 shared Q. Vicens· 2 shared A. Glasgow· 1 shared A. MacFadden· 1 shared D. C. Pineda Rodriguez· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiochemistry

J. S. Kieft

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4 papers

Recent·Most cited

BiochemistrybioRxivPreprintJun 7, 2023

An evolutionarily conserved strategy for ribosome binding and inhibition by β-coronavirus non-structural protein 1

S. F. Maurina, J. P. O'Sullivan, G. Sharma…·A.-L. Steckelberg

This paper identifies conserved ribosome-binding mechanisms in β-coronavirus Nsp1 proteins and shows how a cis-acting RNA element modulates Nsp1 function.

DOI 10.1101/2023.06.07.544141

humanproteomics

BiochemistrybioRxivJun 25, 2020

Different tertiary interactions create the same important 3-D features in a divergent flavivirus xrRNA

R. A. Jones, A.-L. Steckelberg, M. J. Szucs…·J. S. Kieft

The paper identifies an xrRNA in Tamana Bat Virus and shows it achieves a conserved 3D structure through novel tertiary interactions, highlighting sequence and structural diversity in flaviviruses.

DOI 10.1261/rna.077065.120

structural biologyexperimental assay

BiochemistrybioRxivApr 30, 2020

The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

A.-L. Steckelberg, Q. Vicens, D. A. Costantino…·J. S. Kieft

The paper presents the crystal structure of a polerovirus xrRNA, revealing sequence diversity within a conserved fold and explaining conservation patterns and new interactions.

DOI 10.1261/rna.076224.120

plant (other)structural biology

BiochemistrybioRxivFeb 9, 2018

A folded viral noncoding RNA blocks host cell exoribonucleases through programmed remodeling of RNA structure

A.-L. Steckelberg, B. M. Akiyama, D. A. Costantino…·J. S. Kieft

The paper identifies a novel RNA structure-dependent mechanism in dianthoviruses that blocks exoribonucleases, revealing convergent evolution of xrRNAs across unrelated viral families.

DOI 10.1073/pnas.1802429115

experimental assayhost-pathogen & immune response