Author

A. Marciniak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

J. Czub· 2 shared J. Slabonska· 2 shared D. Mitrovic· 1 shared K. A. Hossain· 1 shared L. Delemotte· 1 shared P. Chodnicki· 1 shared S. Sappati· 1 shared Y. Chen· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 11 mutual co-author links

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2 shared papersBiophysics

J. Czub

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3 papers

Recent·Most cited

Low-barrier hydrogen bond determines target-binding affinity and specificity of the antitubercular drug bedaquiline

J. Slabonska, S. Sappati, A. Marciniak, J. Czub

This study investigates how a specific hydrogen bond in bedaquiline contributes to its binding affinity and specificity for mycobacterial ATP synthase, and explores ways to overcome resistance by modifying this interaction.

bioRxiv · Jul 28, 2023Biophysics

Coevolution-driven method for efficiently simulating conformational changes in proteins reveals molecular details of ligand effects in the beta2AR receptor

D. Mitrovic, Y. Chen, A. Marciniak, L. Delemotte

This paper introduces a coevolution-driven method to simulate protein conformational changes, revealing ligand effects on the beta2AR receptor's activation and signaling pathways.

bioRxiv · Jul 20, 2023Biophysics

Determinants of directionality and efficiency of the ATP synthase Fo motor at atomic resolution

A. Marciniak, P. Chodnicki, K. A. Hossain, J. Slabonska, J. Czub

This study uses all-atom simulations to show how the conserved arginine in the ATP synthase Fo motor dictates directionality and efficiency by coordinating protonation and mechanical motion.

bioRxiv · Sep 6, 2021Biophysics