Y. Chen

Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila

The paper shows that lipid metabolism in Drosophila hepatocyte-like cells supports intestinal tumor growth through the TORC1-Hnf4 pathway, with potential therapeutic implications for cancer-associated metabolic dysfunction.

Construction of a GnRH mRNA Immunocastration Vaccine and Evaluation of Its Immunogenicity and Safety in Mice and Cats

This paper develops a GnRH mRNA vaccine using pLS nanoparticles and evaluates its immunogenicity, reproductive suppression, and safety in mice and cats.

microRNA-21 promotes dysregulated lipid metabolism and hepatocellular carcinoma

This study identifies miR-21 as a dysregulated microRNA in MASH-HCC, showing it promotes lipid metabolic changes that contribute to hepatocarcinogenesis in zebrafish models.

Rice Ethylene Receptors Function as Ca2+-Permeable Ion Channels to Orchestrate Calcium-Dependent Antagonism of Ethylene Responses in Roots

The paper identifies OsERS1 and OsERS2 as Ca2+-permeable ion channels in rice roots that mediate calcium-dependent antagonism of ethylene responses.

Spatial task instructions and global activation trends influence functional modularity in the cortical reach network

The paper investigates how task instructions affect cortical network modularity using fMRI data, finding that allocentric tasks reduce module count and recruit additional hubs for integration.

Cnidaria XIAP activates caspase-mediated cell death

This study investigates the function of XIAP in Cnidaria, showing it activates caspase-mediated cell death through BIR and RING domains, unlike its vertebrate counterpart.

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

Integrated Analyses of Multi-omic Data Derived from Paired Primary Lung Cancer and Brain Metastasis Reveals the Metabolic Vulnerability as a Novel Therapeutic Target

This study integrates multi-omic data from lung cancer and brain metastases to identify mitochondrial metabolism as a therapeutic target in brain metastases.

Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

This study identifies a zebrafish model of IBD by knocking out Ctla-4, showing similar intestinal inflammation and immune dysregulation to mammalian IBD.

CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.

The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.

Additive and partially dominant effects from genomic variation contribute to rice heterosis

This study identifies heterosis-associated genes and metabolites in rice, showing additive and partially dominant genetic effects contribute to 17 agronomic traits and yield heterosis across species.

Elucidation of the life cycle of a saprotrophic inoperculate discomycete that is associated with pinesap, using a polyphasic taxonomic approach

This paper re-examines the taxonomy and life cycle of a discomycete fungus associated with pinesap, using phylogenetic and chemical analyses to confirm its identity and complex life cycle.

Pervasive patterns in the songs of passerine birds resemble human music universals and are linked with production and cognitive mechanisms

This study identifies acoustic patterns in bird songs and human music that are shared across species and linked to production and cognitive mechanisms.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

A long non-coding RNA LINC00094 regulates the transcriptional expression of lipid metabolism-related genes as a new member of core regulatory circuitry in esophageal squamous cell carcinoma

This paper identifies LINC00094 as a long non-coding RNA that forms a core regulatory circuitry with TCF3 and KLF5 to regulate lipid metabolism-related genes in esophageal squamous cell carcinoma.

Single-cell resolved differentiation of pre-Kranz anatomy in maize leaf primordia

The paper uses single-nucleus RNA sequencing to study cell heterogeneity and developmental trajectories in maize leaf primordia, identifying potential regulators of Kranz anatomy development.

Network for Knowledge Organization (NEKO): an AI knowledge mining workflow for synthetic biology research

NEKO is an AI workflow using LLMs to extract and organize scientific knowledge from literature, providing more specific and actionable insights than existing models.

Eco-evolutionary Guided Pathomic Analysis to Predict DCIS Upstaging

This study uses ecological analysis of hypoxia and acidosis biomarkers to improve prediction of DCIS upstaging by identifying habitat-based metabolic phenotypes and spatial niches.

PPTC7 acts as an essential co-factor of the SCFFBXL4 ubiquitin ligase complex to restrict BNIP3/BNIP3L-dependent mitophagy

O-Glycosylated RNA Identification and Site-specific Prediction by Solid-phase Chemoenzymatic TnORNA method and PONglyRNA tool

This paper identifies and predicts O-glycosylated RNA using a chemoenzymatic method and a computational tool, revealing their role in pancreatic cancer progression.

Genomic characterization of Escherichia coli harbor a polyketide synthase (pks) island associated with colorectal cancer (CRC) development

This study characterizes the genomic distribution and evolution of pks islands in E. coli strains associated with colorectal cancer, revealing phylogenetic patterns and horizontal gene transfer.

Embracing Uncertainty Reshapes the ETHYLENE INSENSITIVE2-Activated Ethylene Signaling Framework

The paper challenges the current model of ethylene signaling by showing EIN2 activation can occur independently of CTR1, ETP1/ETP2, and MHL1/MHL2, and reveals new interactions and regulatory mechanisms.

Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

Unveiling the PHR-centered regulatory network orchestrating the phosphate starvation signaling in Chinese fir (Cunninghamia lanceolata)

This study identifies ClPHRs as key regulators of phosphate starvation signaling in Chinese fir, revealing evolutionary differences in the SPX-PHR module compared to model plants.

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from individuals exposed only to ancestral SARS-CoV-2.

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

This study shows that AARS2 protects cardiomyocytes from ischemia by modulating PKM2-mediated metabolism, improving cardiac function after myocardial infarction.

Hepatic Macrophage Migration Inhibitory Factor Promotes Pancreatic Cancer Liver Metastasis in NAFLD

This study shows that hepatic MIF promotes PDAC liver metastasis in NAFLD by enhancing cancer stemness and immune suppression through the MIF-CD44 axis.

TAD hierarchy restricts poised LTR activation and loss of TAD hierarchy promotes LTR co-option in cancer

The paper shows that TAD hierarchy restricts LTR activation, and its loss in cancer allows LTRs to act as alternative promoters, driving oncogene activation and transcriptional diversity.

Differential prevalence and risk factors for infection with coronaviruses in bats collected during 2020 in Yunnan Province, China

The paper examines CoV prevalence in bats from Yunnan Province, identifying new SARSr-CoVs and factors influencing their distribution and zoonotic risk.

Inactivation of PRMT1 inhibits cardiac fibrosis via transcriptional regulation and perturbation of FBL activity in fibroblast-to-myofibroblast transition

This study shows that inhibiting PRMT1 reduces cardiac fibrosis by blocking fibroblast-to-myofibroblast transition through transcriptional regulation and disruption of FBL activity.