A critical role for PLCG1 in RAS activation by BCR-ABL1 and FLT3-ITD
M. Y. Szeto, A. Mase, K. Kulhanek, S. Banerjee, I. Rubio, J. Roose, N. P. Shah
This study identifies PLCG1 as a mediator of RAS activation by BCR-ABL1 and FLT3-ITD, showing that PLCG1 inhibition enhances sensitivity to TKIs in CML and AML.
bioRxiv · Apr 7, 2023 · PreprintCancer Biology