Author

J. Roose

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

P. Depeille· 2 shared A. Barczak· 1 shared A. Mase· 1 shared A. Samocha· 1 shared A. Sil· 1 shared B. Joehnk· 1 shared C. Garcia· 1 shared C. Mullighan· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCell Biology

P. Depeille

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A critical role for PLCG1 in RAS activation by BCR-ABL1 and FLT3-ITD

M. Y. Szeto, A. Mase, K. Kulhanek, S. Banerjee, I. Rubio, J. Roose, N. P. Shah

This study identifies PLCG1 as a mediator of RAS activation by BCR-ABL1 and FLT3-ITD, showing that PLCG1 inhibition enhances sensitivity to TKIs in CML and AML.

bioRxiv · Apr 7, 2023 · PreprintCancer Biology

NF-κB inhibitor alpha has a cross-variant role during SARS-CoV-2 infection in ACE2-overexpressing human airway organoids

C. R. Simoneau, P.-Y. Chen, G. X. Xing, M. M. Khalid, N. L. Meyers, J. M. Hayashi, T. Y. Taha, K. E. Leon, T. Ashuach, K. A. Fontaine, L. Rodriguez, B. Joehnk, K. Walcott, S. Vasudevan, X. Fang, , M. Ott

The paper uses ACE2-overexpressing airway organoids to show NF-κB inhibitor alpha is upregulated during SARS-CoV-2 infection and its reduced function increases viral infection.

bioRxiv · Aug 2, 2022 · PreprintMicrobiology

Fine-tuning of Epithelial EGFR signals Supports Coordinated Mammary Gland Development

A. Samocha, H. Doh, V. Sitarama, Q. Nguyen, O. Gbenedio, J. Rudolf, W. Eckalbar, A. Barczak, Y. Miao, C. Garcia, D. Lawson, Z. Werb, K. Kessenbrock, P. Depeille, J. Roose

This study shows that Rasgrp1 fine-tunes EGFR signals in mammary epithelial cells to regulate development during puberty, with in vitro and in vivo effects on proliferation, branching, and cellularity.

bioRxiv · Sep 10, 2020 · PreprintCell Biology

Increased baseline RASGRP1 signals Enhance Stem Cell Fitness during Native Hematopoiesis

L. Karra, D. Romero-Moya, O. Ksionda, M. Krush, Z. Gu, M. Mues, P. Depeille, C. Mullighan, J. Roose

This study shows that increased RASGRP1 signaling enhances stem cell fitness in native hematopoiesis but does not cause acute leukemia on its own.

bioRxiv · Jun 24, 2020Cancer Biology