S. Banerjee

High throughput cell mechanotyping of cell response to cytoskeletal modulations using a microfluidic cell deformation system

This paper develops a microfluidic system for high-throughput mechanotyping of cells to study cytoskeletal modulations and their effects on cellular mechanics.

Growth-induced collective bending and kinetic trapping of cytoskeletal filaments

This study develops a model showing that rapid actin filament growth leads to kinetic trapping of bent filaments, influenced by subunit availability and crosslinking.

Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening

The paper investigates how condensate material properties and chromatin heterogeneity influence nuclear condensate growth, revealing two physical mechanisms and a quantitative theory to explain these dynamics.

Endothelial ERG programs neutrophil transcriptome for sustained anti-inflammatory vascular niche

This study shows that endothelial ERG regulates neutrophil transcriptome to create an anti-inflammatory vascular niche, preventing excessive inflammation.

RV-specific Targeting of Snai1 Rescues Pulmonary Hypertension-induced Right Ventricular Failure by Inhibiting EndMT and Fibrosis via LOXL2 Mediated Mechanism

This study shows that targeting Snai1 in the right ventricle rescues pulmonary hypertension-induced failure by reducing EndMT, fibrosis, and FMT through a LOXL2-dependent mechanism.

Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis

This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.

Cross Modal Correspondence based MultisensoryIntegration: A pilot study showing how HAV cues can modulate the reaction time.

This study investigates how haptic cues can modulate reaction times in multisensory integration using EEG-based BCI, showing that congruent sequential cues yield faster responses than incongruent haptic-auditory-visual (HAV) cues.

Heterotypic Seeding Generates Mixed Amyloid Polymorphs

This study shows that Aβ can form mixed polymorphs with different seeds, deviating from its typical parallel β structure, and highlights the complexity of Aβ aggregation in Alzheimer's disease.

The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function

This study identifies BLTP2 as a pro-survival protein that regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function, linking it to cancer aggressiveness.

Energy allocation theory for bacterial growth control in and out of steady state

The paper develops a theory of dynamic energy allocation to model bacterial growth and morphology under varying environmental conditions, capturing experimentally observed relationships and predicting nutrient-dependent trade-offs.

Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis

The paper shows that mechanical and biochemical feedbacks combine to create complex contractile oscillations during cytokinesis.

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

This study shows PKC inhibition reduces iron overload in diabetes and hemochromatosis by modulating ferroportin expression and trafficking.

Horizontally transferred cell-free chromatin particles function as autonomous satellite genomes and vehicles for transposable elements within host cells

Establishment of an intragastric surgical model using C57BL/6 mice to study the vaccine efficacy of OMV-based immunogens against Helicobacter pylori

The paper establishes a surgical model in C57BL/6 mice to study OMV-based vaccine efficacy against H. pylori, showing protective immunity after immunization.

Hippo effector, Yorkie, is a Tumor Suppressor in Select Drosophila Squamous Epithelia

This study shows that Yki signaling suppresses PI3K/Akt/TOR in Drosophila squamous epithelia, preventing tumor formation, and that its loss leads to cancer-like changes in multiple tubular organs.

RGS2 is an innate immune checkpoint for TLR4 and Gαq-mediated IFNγ generation and lung injury

This study shows RGS2 limits IFNγ production in alveolar macrophages by inhibiting TLR4-Gαq signaling, reducing lung injury in mice and correlating with ARDS patient data.

Machine Learning Guided Differentiation Therapy Targets Cancer Stem Cells in Colorectal Cancers

This paper introduces a machine learning framework to identify and target transcriptomic vulnerabilities in colorectal cancer, demonstrating that differentiation therapy selectively eliminates cancer stem cells and reduces recurrence risk.

α-Synuclein emulsifies TDP-43 prion-like domain - RNA liquid droplets to promote heterotypic amyloid fibrils

This study shows α-synuclein emulsifies TDP-43 prion-like domain-RNA droplets, promoting heterotypic amyloid fibril formation.

Mechanical control of cell proliferation patterns in growing tissues

The paper develops a computational model to predict cell proliferation patterns in growing tissues, showing mechanical feedback influences growth dynamics and boundary proliferation.

Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter-like features

The study analyzes recombination patterns in corn snakes to show that both PRDM9 and promoter-like features influence recombination, revealing a competitive interaction between these mechanisms.

Differences in Hepatocellular Iron Metabolism Underlie Sexual Dimorphism in Hepatocyte Ferroptosis

This study identifies sex differences in hepatocyte ferroptosis, showing males are more susceptible due to differences in iron metabolism and FSP1 regulation.

Development and Optimisation of in vitro Sonodynamic Therapy for Glioblastoma

The paper develops an automated in vitro sonodynamic therapy system for glioblastoma and demonstrates its efficacy in inducing apoptosis and reducing 3D growth of glioma cells.

Catalytic growth in a shared enzyme pool ensures robust control of centrosome size

The paper introduces a catalytic growth model for centrosome size regulation, showing it achieves robust size equality across organisms.

Unveiling the Domain-Specific and RAS Isoform-Specific Details of BRAF Regulation

This study investigates BRAF activation mechanisms by analyzing domain-specific and RAS isoform-specific interactions using experimental assays.

Intermediate antiparallel beta structure in amyloid plaques revealed by infrared spectroscopic imaging

The paper uses infrared spectroscopic imaging to show that amyloid plaques in Alzheimer's disease contain antiparallel beta-sheet structures, linking in vitro findings to in vivo pathology.

A critical role for PLCG1 in RAS activation by BCR-ABL1 and FLT3-ITD

This study identifies PLCG1 as a mediator of RAS activation by BCR-ABL1 and FLT3-ITD, showing that PLCG1 inhibition enhances sensitivity to TKIs in CML and AML.

Plant cellulose synthase membrane protein isolation directly from Pichia pastoris protoplasts, liposome reconstitution, and its enzymatic characterization

This paper develops a method to isolate and characterize plant cellulose synthase enzymes from Pichia pastoris protoplasts, achieving higher yields and functional reconstitution into liposomes.

Intermediate antiparallel fibrils in Aβ40 Dutch mutant aggregation: nanoscale insights from AFM-IR

This study uses AFM-IR to analyze the structural evolution of Aβ40 Dutch mutant (E22Q) aggregates, revealing bimodal oligomers and antiparallel fibrils that persist through aggregation stages.

Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ: explained by strain energy

This study compares the force-regulated chaperone activity of tunnel-associated BiP/ERdj3 and their cytoplasmic homologs DnaK/DnaJ, revealing that BiP/ERdj3 act as foldases under force while DnaK/DnaJ act as holdases.

A novel role of macrophage PIST protein in regulating Leishmania major infection

This study shows that macrophage PIST protein regulates Leishmania major infection by interacting with Beclin 1 and affecting parasite replication.