Melanoma-derived DNA polymerase theta variants exhibit altered DNA polymerase activity
C. Thomas, L. Avalos-Irving, J. Victorino, S. Green, M. Andrews, N. Rodrigues, S. Ebirim, A. Mudd, J. B. Towle-Weicksel
The paper identifies POLQ gene mutations in melanoma tumors and shows they reduce DNA polymerase activity and accuracy, potentially contributing to cancer progression.
bioRxiv · Nov 14, 2023Biochemistry