C. Thomas

Blood-based detection of MMP11 as a marker of prostate cancer progression regulated by the ALDH1A1-TGF-β1 signaling mechanism

This study identifies MMP11 as a blood-based biomarker for prostate cancer progression, regulated by the ALDH1A1-TGF-β1 signaling pathway.

A protective role for B-1 cells and oxidation-specific epitope IgM in lung fibrosis

This study shows B-1 cells and IgMOSE reduce lung fibrosis by modulating CXCR4 and Id3, with sIgM-/- mice showing increased mortality from bleomycin injury.

The effects of clay minerals on bacterial community composition during arthropod decay

The paper examines how different clay minerals affect bacterial communities during arthropod decay, finding that kaolinite reduces bacterial diversity and increases gram-negative bacteria.

Melanoma-derived DNA polymerase theta variants exhibit altered DNA polymerase activity

The paper identifies POLQ gene mutations in melanoma tumors and shows they reduce DNA polymerase activity and accuracy, potentially contributing to cancer progression.

A monoclonal antibody collection for C. difficile typing

The paper develops a monoclonal antibody collection targeting C. difficile strains to improve research on clinically relevant ribotypes.

Atheroma plaque microenvironment stimulates kynurenine production by macrophages to induce endothelial adhesion molecules in the context of atherogenesis

This study shows that atheroma plaque microenvironment activates the kynurenine pathway in macrophages, increasing kynurenine production which induces endothelial adhesion molecules, promoting atherogenesis.

The minus end depolymerase KIF2A drives flux-like treadmilling of γTuRC-uncapped microtubules

This study shows KIF2A drives treadmilling of γTuRC-uncapped microtubules by depolymerizing minus ends while allowing nucleation from γTuRC.

The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

This study shows TAPBPR promotes UGGT1-mediated reglucosylation of peptide-free MHC I during quality control.

Thiovibrio frasassiensis gen. nov., sp. nov., an autotrophic, elemental sulfur disproportionating bacterium isolated from sulfidic karst sediment, and proposal of Thiovibrionaceae fam. nov.

This paper describes a novel sulfur-disproportionating bacterium isolated from cave sediments, proposing a new genus and family based on phylogenetic and genomic analysis.

N-linked glycosylation increases horse radish peroxidase rigidity leading to enhanced activity and stability.

This study shows glycosylation increases the rigidity of horseradish peroxidase, enhancing its activity and stability through structural changes.

Compromised CDK12 activity causes dependency on the non-essential spliceosome components

This study shows that compromised CDK12 activity in prostate cancer cells leads to addiction to non-essential spliceosome components and lower DNA methylation, suggesting potential therapeutic targets.

mTOR Inhibition Overcomes RSK3-mediated Resistance to BET Inhibitors in Small Cell Lung Cancer

This study identifies mTOR inhibition as a strategy to overcome RSK3-mediated resistance to BET inhibitors in small cell lung cancer, enhancing apoptosis and antitumor efficacy.

Therapeutic reversal of prenatal pontine ID1 signaling in DIPG

This study identifies ID1 upregulation in DIPG tumor cells and shows that CBD can reduce ID1-driven invasiveness in vitro and in vivo.

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

A Kiosk Station for the Assessment of Multiple Cognitive Domains and Enrichment of Monkeys

This paper introduces a Kiosk Station for running cognitive tasks in cage-housed monkeys, showing high engagement and consistency in cognitive performance.

O-GlcNAc regulates gene expression by controlling detained intron splicing

This study shows O-GlcNAc modification regulates detained intron splicing, affecting gene expression and linking nutrient conditions to transcriptional regulation.

Pharmacologic activation of the mitochondrial phosphoenolpyruvate cycleenhances islet function in vivo

This study shows that pharmacologic activation of pyruvate kinase (PK) enhances insulin secretion in preclinical diabetes models by stimulating the mitochondrial phosphoenolpyruvate (PEP) cycle.

Spatial distribution and research trend of illegal activities and the factors associated with wild mammal population declines in protected areas

This study analyzes the spatial distribution of illegal activities and their impact on wild mammal population declines in protected areas, finding that commercial poaching, low human development, and large body size increase vulnerability.

A Homogeneous SIRPα-CD47 Cell-Based, Ligand-Binding Assay: Utility for Small Molecule Drug Development in Immuno-oncology.

This paper develops a cell-based ligand-binding assay to identify small molecule inhibitors of the SIRP-CD47 interaction for immuno-oncology drug development.

Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1

This study identifies a novel mechanism in mouse oocytes that ensures synchronous chromosome segregation through biphasic securin destruction and cyclin B1-Cdk1 inhibition of separase.

The speed of GTP hydrolysis determines GTP cap size and controls microtubule stability

This study shows that GTP hydrolysis speed affects GTP cap size and microtubule stability by influencing EB protein binding and regulatory hub formation.

Intraspecific interactions in the annual legume Medicago minima are shaped by both genetic variation for competitive ability and reduced competition among kin.

The paper tests how genetic variation and kinship influence intraspecific competition in Medicago minima, finding both competitive ability and kin avoidance affect plant growth.

Spectrin is a mechanoresponsive protein shaping the architecture of intercellular invasion

The paper shows spectrin dynamically accumulates at fusogenic synapses in response to shear deformation, forming a sieve-like network that promotes cell membrane fusion during intercellular invasion.

MicroRNA-451a regulates colorectal cancer radiosensitivity

This study identifies miR-451a as a regulator of colorectal cancer radiosensitivity, showing it inhibits proliferation and enhances radiation response.