M. Andrews

KR158 spheres harboring slow-cycling cells recapitulate GBM features in an immunocompetent system

This study validates a murine model of glioblastoma stem cells that recapitulate human features and enables investigation of their interactions with the immune system.

Melanoma-derived DNA polymerase theta variants exhibit altered DNA polymerase activity

The paper identifies POLQ gene mutations in melanoma tumors and shows they reduce DNA polymerase activity and accuracy, potentially contributing to cancer progression.

Prospective isolation according to melanin pigment content of melanoma cells with heterogeneous potentials for disease propagation

This study isolates melanoma cells based on melanin content, finding that low-pigment cells are more abundant and have higher tumorigenic potential than high-pigment cells.

Kiawah and Seabrook islands are a critical site for the rufa red knot (Calidris canutus rufa)

The paper estimates the population and stopover duration of rufa red knots at Kiawah and Seabrook islands and identifies a network of coastal sites critical for their migration.

Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression via GTP

This paper identifies a non-canonical, methyltransferase-independent mechanism by which EZH2 promotes melanoma progression through interactions with IMPDH2 and GTP synthesis.

Shorter constant work rate cycling tests as proxies for longer tests in highly trained cyclists

This study shows that a 2-minute constant work rate cycling test can serve as a proxy for a 4-minute test in highly trained cyclists, as it correlates strongly with longer test outcomes while being less fatiguing.

EZH2 Abundance Regulated by UHRF1/UBE2L6/UBR4 Ubiquitin System is the Potential Therapeutic Target to Trigger Pigmented Phenotype in Melanoma

The paper identifies the UHRF1/UBE2L6/UBR4 ubiquitin system as a regulator of EZH2 abundance, which controls pigmentation in melanoma by influencing melanin biosynthesis.

Molecular basis for feedback inhibition of Notch signaling by the Notch regulated ankyrin repeat protein NRARP

This study identifies the molecular mechanism by which NRARP inhibits Notch signaling by binding to the NTC complex and disrupting its function.