Author

A. P. Bye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

J. den Dunnen· 2 shared J. M. Gibbins· 2 shared W. Hoepel· 2 shared A. P. J. Vlaar· 1 shared Amsterdam UMC COVID-19 Biobank· 1 shared C. E. Geyer· 1 shared D. Guerra· 1 shared G. R. Griffith· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

J. den Dunnen

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2 papers

Recent·Most cited

Identification of new drugs to counteract anti-spike IgG-induced hyperinflammation in severe COVID-19

C. E. Geyer, H.-J. Chen, A. P. Bye, X. D. Manz, D. Guerra, T. G. Caniels, T. P. L. Bijl, G. R. Griffith, W. Hoepel, S. W. de Taeye, J. Veth, A. P. J. Vlaar, Amsterdam UMC COVID-19 Biobank, G. Vidarsson, H. J. Bogaard, , J. den Dunnen

The paper identifies SYK and PI3K inhibitors, particularly entospletinib, as effective in counteracting anti-spike IgG-induced hyperinflammation in severe COVID-19.

bioRxiv · Dec 20, 2022Immunology

Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets

A. P. Bye, W. Hoepel, J. L. Mitchell, S. Jegouic, S. Loureiro, T. Sage, S. de Taeye, M. van Gils, N. Kriek, N. Cooper, I. Jones, J. den Dunnen, J. M. Gibbins

The paper shows that aberrant glycosylation of anti-SARS-CoV-2 IgG enhances platelet activation and thrombosis via FcyRIIA, which can be inhibited by tyrosine kinase inhibitors and P2Y12 antagonists.

bioRxiv · Mar 26, 2021Immunology