ImmunologybioRxiv
Aberrant glycosylation of anti-SARS-CoV-2 IgG is a pro-thrombotic stimulus for platelets
A. P. Bye, W. Hoepel, J. L. Mitchell…·J. M. Gibbins
The paper shows that aberrant glycosylation of anti-SARS-CoV-2 IgG enhances platelet activation and thrombosis via FcyRIIA, which can be inhibited by tyrosine kinase inhibitors and P2Y12 antagonists.
DOI 10.1182/blood.2021011871