Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma
A. K. Coley, C. Nawrocki, B. K. Patel, A. Pankaj, Z. Guo, M. J. Emmett, E. R. Lang, Y. Song, K. H. Xu, C. R. Ferrone, V. Deshpande, L. T. Nieman, M. Aryee, J. W. Franses, D. T. Ting
This study uses single cell spatial transcriptomics to show LINE1 repeat RNA expression in HCC correlates with a disorganized immune microenvironment and poor patient survival.
bioRxiv · Dec 4, 2023 · PreprintCancer Biology