Z. Guo

Mutation of phosphatidate phosphohydrolase genes confers broad-spectrum disease resistance in plants

The paper shows that mutating phosphatidate phosphohydrolase (PAH) genes in rice and Arabidopsis increases phosphatidic acid (PA) levels and broad-spectrum disease resistance.

Exenatide administration time determines the effects on blood pressure dipping in db/db mice via modulation of food intake and sympathetic activity

This study shows that exenatide administration time affects blood pressure dipping in db/db mice by altering food intake and sympathetic activity, with efficacy dependent on food availability and circadian timing.

Revealing the Biophysics of Lamina-Associated Domain Formation by Integrating Theoretical Modeling and High-Resolution Imaging

This study combines theoretical modeling and high-resolution imaging to reveal how chromatin-lamina interactions and environmental cues influence LAD formation and thickness in hMSCs.

Sampling Conformational Ensembles of Highly Dynamic Proteins via Generative Deep Learning

This paper introduces a deep learning model to sample conformational ensembles of dynamic proteins, demonstrating its ability to generate novel conformations and rationalize experimental findings.

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

All-atom protein sequence design based on geometric deep learning

This paper introduces GeoSeqBuilder, a geometric deep learning framework for protein sequence design that achieves high accuracy in recovering native residues and predicting side-chain conformations.

Click-free imaging of carbohydrate trafficking in live cells using an azido photothermal probe

This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.

The impact of Bacillus coagulans X3 on available nitrogen content, bacterial community composition, and nitrogen functional gene levels when composting cattle manure

This study examines how adding Bacillus coagulans X3 to cattle manure compost affects nitrogen levels, bacterial communities, and nitrogen-related genes.

Ketone body 3-hydroxybutyrate alleviates CCl4-induced liver fibrosis in mice through regulation of mitochondrial fission and reduction of oxidative stress

This study shows that 3-hydroxybutyrate reduces liver fibrosis in mice by improving mitochondrial function and reducing oxidative stress.

Defining cell type-specific immune responses in a mouse model of allergic contact dermatitis by single-cell transcriptomics

This study uses single-cell transcriptomics to identify cell type-specific immune responses in a mouse model of allergic contact dermatitis, highlighting the role of dermal fibroblasts in type-1 inflammation.

Highly Multiplexed Fluorescence Microscopy with Spectrally Tunable Semiconducting Polymer Dots

This paper introduces a method for highly multiplexed fluorescence microscopy using tunable semiconducting polymer dots, enabling imaging of up to 21 targets in a single round.

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma

This study uses single cell spatial transcriptomics to show LINE1 repeat RNA expression in HCC correlates with a disorganized immune microenvironment and poor patient survival.

Antiviral humoral immunity against SARS-CoV-2 Omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive and XBB-infected individuals

The paper assesses the humoral immune response to XBB.1.5 vaccine in infection-naive and XBB-infected individuals against various SARS-CoV-2 variants.

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

Thiolation-Based Protein-Protein Hydrogels for Improved Wound Healing

This paper develops protein-protein hydrogels using thiolation and Ag-S bonding to enhance wound healing properties in both diabetic and UV-burn models.

Ex vivo structures from spinach leaves

The paper reports the structures of ten protein complexes from spinach leaves using a new ex vivo method that enables cryoEM-based high-resolution structure determination without genome manipulation or high-affinity binders.

Nanoscale Structural Mapping of Protein Aggregates in Live Cells Modeling Huntington's Disease

This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.

Daptomycin forms a stable complex with phosphatidylglycerol for selective uptake to bacterial membrane

This paper reveals that daptomycin forms a stable complex with phosphatidylglycerol and calcium for selective bacterial membrane uptake, explaining its mechanism and potential resistance strategies.

Transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant

This study investigates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant, finding it to be highly immune evasive but with lower infectivity compared to other variants.

Antibody inhibition of influenza A virus assembly and release

This study investigates how antibodies inhibit influenza A virus assembly and release, finding that some antibodies restrict viral egress at higher concentrations than entry inhibition and alter virion morphology.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

High red/far-red ratio promotes root colonization of Serratia plymuthica A21-4 in tomato by root exudates-stimulated chemotaxis and biofilm formation

Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

Ancient DNA in Lycoptera Fossils: Key Discoveries for Evolution and Methodological Reassessment

The paper extracts and analyzes ancient DNA from Lycoptera davidi fossils, identifies original DNA fragments, and introduces a new method for aDNA analysis and a novel genomic mechanism.

Targeted Protein O-GlcNAcylation Using Bifunctional Small Molecules

This paper develops OGTACs, bifunctional small molecules that enable protein-specific O-GlcNAcylation in cells, with applications for studying and targeting this modification in disease.

Genetically Encodable in situ Gelation Redox-Responsive Collagen-Like Protein Hydrogel for Accelerating Diabetic Wound Healing

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

Seasonal Variation in Bacterial Community Structures of Mangrove Sediments

This study examines seasonal variations in mangrove sediment bacterial communities and identifies factors influencing their assembly mechanisms.

Active Transcription and Epigenetic Reactions Synergistically RegulateMeso-Scale Genomic Organization

This study introduces a mesoscale model to show how transcription and epigenetic reactions regulate heterochromatin domain sizes, finding that transcription loss increases domain size and compaction.

A scalable, GMP-compatible, autologous organotypic cell therapy for Dystrophic Epidermolysis Bullosa

This paper develops a scalable, GMP-compatible cell therapy for Dystrophic Epidermolysis Bullosa using CRISPR-corrected iPS cells to generate functional skin grafts.