The anti-angiogenic compound dimethyl fumarate inhibits the serine synthesis pathway and increases glycolysis in endothelial cells
M. C. Ocana, C. Yang, M. Bernal, B. Martinez-Poveda, H. S. Vu, C. Cardenas, R. J. DeBerardinis, A. R. Quesada, M. A. Medina
This study shows dimethyl fumarate inhibits serine synthesis and increases glycolysis in endothelial cells, potentially explaining its anti-angiogenic effects.
bioRxiv · Dec 13, 2021 · PreprintBiochemistry