C. Yang

A novel proliferative candidate genes panel for idiopathic pulmonary fibrosis: insights from integrated bulk and single-cell RNA sequencing

This study identifies a proliferative gene module in IPF using bulk and single-cell RNA-seq, linking it to cell cycle and oncogenic pathways, suggesting potential therapeutic targets.

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss

The paper investigates gene loss in Vibrio parahaemolyticus pandemic clones, showing it drives wave succession through environmental and transmission advantages.

Wireless, Multimodal Monitoring of Organ Health Using 3D-Printed, Barbed, Bioresorbable Stretchable Microneedle Sensor Arrays

This paper introduces a wireless, 3D-printed microneedle sensor array for multimodal organ monitoring, capable of measuring metabolism, oxygenation, and electrophysiology with spatiotemporal resolution.

Elevational constraints on flight efficiency shape global gradients in avian wing morphology

This study finds that avian wing morphology changes with elevation, showing increased wing elongation and area at higher elevations, supporting aerodynamic constraints as a driver of trait evolution.

CCDC32 stabilizes clathrin-coated pits and drives their invagination

This study identifies CCDC32 as an endocytic accessory protein that stabilizes clathrin-coated pits and drives their invagination, with mutations linked to cardio-facio-neuro-developmental syndrome.

Brain-derived exosomal hemoglobin transfer contributes to neuronal mitochondrial homeostasis under hypoxia

This study identifies exosomal hemoglobin transfer from non-neuronal cells to neurons under hypoxia as a mechanism to maintain mitochondrial homeostasis and protect against neurological injury.

Deciphering the Preeclampsia-Specific Immune Microenvironment: The Role of Pro-inflammatory Macrophages

This study identifies pro-inflammatory macrophages as key regulators of the PE-specific immune microenvironment, linking them to Th17 and CD8+ T cell activation and gMDSC suppression in placental tissues.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

Skeletal Muscle Specific PolG Dysfunction Activates the Integrated Stress Response and Promotes a Cachexia like Phenotype

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

Long-term imaging of three-dimensional hyphal development using the ePetri dish

The paper introduces an upgraded ePetri dish system for long-term 3D microbial imaging, demonstrating its ability to monitor hyphal development and detect filter failures.

LncCE: Landscape of Cellular-Elevated LncRNAs in Single Cells Across Normal and Cancer Tissues

LncCE identifies and characterizes cellular-elevated lncRNAs across normal and cancer tissues using single-cell RNA sequencing data, providing expression patterns and clinical associations.

Three cytochrome P450 from Nicotiana attenuata play key roles in triterpene biosynthesis

Three CYP716 enzymes in Nicotiana attenuata catalyze distinct steps in triterpene biosynthesis, influencing growth and development through ABA and stress responses.

PEX39 facilitates the peroxisomal import of PTS2 proteins

This study identifies PEX39 as a cytosolic peroxin that facilitates PTS2-protein import by interacting with PEX7 and stabilizing its binding to cargo.

Unlocking TAS2R14 activation through intricate multi-ligand binding networks

The paper presents cryo-EM structures of TAS2R14 with ligands and G proteins, revealing multi-ligand binding sites and activation mechanisms.

Myosin A and F-Actin play a critical role in mitochondrial dynamics and inheritance in Toxoplasma gondii

This study identifies Myosin A and F-Actin as critical for mitochondrial dynamics and inheritance in Toxoplasma gondii through interactions with LMF1 and IMC10.

Non-invasive laser speckle imaging of extra-embryonic blood vessels in intact few-days-old avian eggs

The paper demonstrates non-invasive laser speckle imaging for visualizing blood vessels in avian eggs and monitoring embryonic development with machine learning.

Design and optimization of novel succinate dehydrogenase inhibitors against agricultural fungi based on Transformer model

This study uses a Transformer model to design novel succinate dehydrogenase inhibitors against agricultural fungi, resulting in potent antifungal compounds through virtual screening and optimization.

Investigating 3D microbial community dynamics in the rhizosphere using complex-field and fluorescence microscopy

This paper introduces CFAST, a novel imaging technique for 3D microbial community dynamics in the rhizosphere, enabling non-invasive tracking of bacterial behavior and gene expression without genetic labeling.

Large-scale multi-omics analyses identified root-microbiome associations underlying plant nitrogen nutrition

The paper identifies root-microbiome associations affecting plant nitrogen nutrition through multi-omics analyses of 1,341 rapeseed samples.

KR158 spheres harboring slow-cycling cells recapitulate GBM features in an immunocompetent system

This study validates a murine model of glioblastoma stem cells that recapitulate human features and enables investigation of their interactions with the immune system.

Chromosome-scale genome assembly of bread wheat's wild relative Triticum timopheevii

This study presents a chromosome-scale genome assembly of Triticum timopheevii using PacBio HiFi and Hi-C data, revealing genomic features and relationships between wheat genomes.

ASY3 has dosage-dependent diverse effects on meiotic crossover formation

This study shows that ASY3 dosage affects crossover formation in Brassica napus, with reduced dosage increasing crossover numbers and disrupting interference.

TaNF-Y-PRC2 orchestrates temporal control of starch and protein synthesis in wheat

This study identifies the TaNF-Y-PRC2 complex as a regulator of starch and protein synthesis in wheat endosperm, revealing its role in epigenetic control through histone modification and gene repression.

Exploration of the intricacies of low light-induced changes in cigar tobacco leaf anticlinal growth: A holistic approach from anatomical and hormonal levels to gene expression

This study examines how low light affects cigar tobacco leaf morphology, growth rates, and gene expression, revealing hormonal and cellular changes in leaf structure.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.

Lithocholic acid targets TULP3 to activate sirtuins and AMPK to retard ageing

This study identifies LCA's mechanism of action through TULP3-sirtuin-v-ATPase-AMPK pathway to activate AMPK and extend lifespan in model organisms.

Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor

This study identifies the D2 domain of DTX3L as critical for forming oligomeric complexes that enable the DTX3L-PARP9 complex to read mono-ADP-ribosylated androgen receptor.

MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality

This study shows that LXY18 selectively kills MYC-overexpressing cancer cells by inducing mitotic arrest, offering a new approach to target MYC-driven tumors.

The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer

This paper shows that MARCHF8 stabilizes HPV E7 by degrading CUL1 and UBE2L3, preventing E7 degradation in HPV+ HNC cells.

Transport and inhibition mechanism for VMAT2-mediated synaptic loading of monoamines

This study presents cryo-EM structures of VMAT2 bound to substrates and inhibitors, revealing conformational changes and mechanisms of ligand recognition and inhibition.