Spatio-temporal analysis of human preimplantation development reveals dynamics of epiblast and trophectoderm
D. Meistermann, S. Loubersac, A. Reigner, J. Firmin, V. Francois - - Campion, S. Kilens, Y. Lelievre, J. Lammers, M. Feyeux, P. Hulin, S. Nedellec, B. Bretin, S. Covin, G. Castel, A. Bihouee, , L. David
This study uses transcriptomic pseudotime modeling and spatial data to reveal lineage specification dynamics in human preimplantation embryos, showing TE and ICM differentiation occurs at the blastocyst stage.
bioRxiv · Apr 10, 2019Cell Biology