L. David

Fatiguing Exercise Reduces Cellular Passive Young's Modulus in Human Vastus Lateralis Muscle

This study shows fatiguing exercise reduces cellular passive Young's modulus in male human muscle but not female, linked to titin phosphorylation changes.

SMAC mimetics overcome apoptotic resistance in ovarian cancer through MSLN-TNF alpha axis

This study shows SMAC mimetics overcome apoptotic resistance in ovarian cancer by targeting the MSLN-TNF alpha axis, enhancing cell death and synergizing with chemotherapy.

Combinatory differentiation of human induced pluripotent stem cells generates thymic epithelium that supports thymic crosstalk and directs dendritic- and CD4/CD8 T-cell full development

This study generates functional thymic epithelial cells from iPSCs that support T cell development and dendritic cell differentiation in vitro.

Single cell analysis reveals CD45RClow/-TNFR2+CD29lowCD8+ Tregs with superior activity

The paper identifies and characterizes three subsets of human CD8+ regulatory T cells using single-cell CITE-seq and VDJ sequencing, highlighting a subset with superior suppressive activity.

NINJ1 mediates plasma membrane rupture through formation of nanodisc-like rings

This study identifies NINJ1's role in membrane rupture through ring formation and amphipathic helices, distinguishing it from NINJ2.

HlyF, an underestimated virulence factor of uropathogenic Escherichia coli

The paper identifies HlyF as a virulence factor in UPEC strains associated with severe UTIs and urosepsis, showing its link to plasmid-mediated virulence and antimicrobial resistance.

ROS-dependent palmitoylation is an obligate licensing modification for GSDMD pore formation

This study identifies palmitoylation as a required modification for GSDMD pore formation, showing that ROS induces this modification and is essential for membrane translocation and cell death.

Piezo mechanosensory channels regulate centrosome integrity

This study shows Piezo1 and 2 regulate centrosome integrity by modulating Ca2+ levels through mechanotransduction of cell intrinsic forces.

Full-length NLRP3 forms oligomeric cages to mediate NLRP3 sensing and activation

This study identifies full-length NLRP3 as a membrane-localized oligomeric cage that senses stimuli and activates the inflammasome, distinct from other monomeric inflammasome sensors.

Highly Efficient Knockin in Human iPS Cells and Rat Embryos by CRISPR/Cas9 Molecular Optimization

This study optimizes CRISPR/Cas9 reagent concentrations for efficient knockin in human iPS cells and rat embryos, achieving 50% knockin efficiency with reduced costs and toxicity.

Identification of DIR1-dependant cellular responses required for guard cell systemic acquired resistance

The paper identifies DIR1-dependent molecular changes in guard cells during systemic acquired resistance using multi-omics, revealing two 18C fatty acids as potential SAR-related molecules.

Outer membrane vesicles produced by pathogenic strains of Escherichia coli block autophagic flux and exacerbate inflammasome activation

The paper shows that OMVs from pathogenic E. coli block autophagic flux and enhance inflammasome activation, contributing to disease severity.

Generation of human induced trophoblast stem cells

This study generates human induced trophoblast stem cells (hiTSC) from post-natal cells using reprogramming and fate conversion, enabling diverse genetic modeling of placental development and disease.

Novel mode of filament formation in UPA-promoted CARD8 and NLRP1 Inflammasomes

This study reports cryo-EM structures of NLRP1-CT and CARD8-CT inflammasome assemblies, revealing unique filament formation mechanisms and ASC recruitment specificity.

Distribution and abundance of bottlenose dolphin (Tursiops truncatus) over the French Mediterranean continental shelf

The paper estimates the size of the bottlenose dolphin population in French Mediterranean waters using photo-identification and capture-recapture methods, finding 557 individuals.

Spatio-temporal analysis of human preimplantation development reveals dynamics of epiblast and trophectoderm

This study uses transcriptomic pseudotime modeling and spatial data to reveal lineage specification dynamics in human preimplantation embryos, showing TE and ICM differentiation occurs at the blastocyst stage.

Chitosan films for microfluidic studies of single bacteria and perspectives for antibiotics susceptibility testing

This paper develops chitosan films for single-cell microfluidics to study bacterial growth and antibiotic susceptibility, achieving faster and more accurate results than current methods.

Mechanism of pharmacochaperoning in KATP channels revealed by cryo-EM

This study reveals how pharmacochaperones stabilize KATP channels by binding to SUR1 and supporting Kir6.2 N-terminus insertion, enabling mutant channel assembly.