Development and characterization of pFluor50, a fluorogenic-based kinetic assay system for high-throughput inhibition screening and characterization of time-dependent inhibition and inhibition type for six human CYPs
P. Shriwas, A. Revnew, S. Roo, A. Bender, T. R. Lane, S. Ekins, C. A. McElroy
The paper develops pFluor50, a fluorogenic kinetic assay system for high-throughput inhibition screening of six human CYPs, determining KM, Vmax, and inhibition types.
bioRxiv · Aug 15, 2023Pharmacology & Toxicology