A. Bender

SLC7A5 is required for citrulline-dependent growth in arginine limited conditions

This study identifies SLC7A5 as essential for citrulline-dependent growth in arginine-limited conditions and shows its role in citrulline uptake and tumor growth.

A Decade in a Systematic Review: The Evolution and Impact of Cell Painting

This paper reviews methodological advancements in Cell Painting over a decade, highlighting improvements in protocols, feature extraction, and machine learning applications for biological insights.

Development and characterization of pFluor50, a fluorogenic-based kinetic assay system for high-throughput inhibition screening and characterization of time-dependent inhibition and inhibition type for six human CYPs

The paper develops pFluor50, a fluorogenic kinetic assay system for high-throughput inhibition screening of six human CYPs, determining KM, Vmax, and inhibition types.

From Pixels to Phenotypes: Integrating Image-Based Profiling with Cell Health Data Improves Interpretability

This study introduces BioMorph space, which integrates Cell Painting and Cell Health data to improve the interpretability of morphological features and reveal compound mechanisms of action.

Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature

This study uses cell morphological profiling to identify phenotypic signatures of PROTACs, revealing mitotoxicity that cannot be predicted from individual components.

A mitochondrial long-chain fatty acid oxidation defect leads to uncharged tRNA accumulation and activation of the integrated stress response in the mouse heart

Deficiency of peroxisomal L-bifunctional protein (EHHADH) causes male-specific kidney hypertrophy and proximal tubular injury in mice

This study shows that EHHADH deficiency in mice causes male-specific kidney hypertrophy and proximal tubular injury, linked to androgen effects on peroxisomal metabolism.

Glutaric aciduria type 3 is a naturally occurring biochemical trait in inbred mice of 129 substrains

The paper identifies glutaric aciduria type 3 as a naturally occurring trait in 129 substrain mice due to SUGCT deficiency, showing its impact on metabolite accumulation.

Systematic analysis of protein targets associated with adverse events of drugs from clinical trials and post-marketing reports

This study systematically analyzes links between drug off-target proteins and adverse events using clinical trial and post-marketing data to improve safety profiling.

Modelling geospatial distributions of the triatomine vectors of Trypanosoma cruzi in Latin America

This paper models the geospatial distributions of 30 triatomine vector species in Latin America and shows most have potential to transmit Trypanosoma cruzi to humans.

Distinct oncogenes drive distinct genome and epigenome alterations in human mammary epithelial cells

This study shows that activating different oncogenes in human mammary epithelial cells leads to distinct genetic and epigenetic changes, suggesting oncogene activation shapes breast cancer subtypes.