Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination
A. L. ten Hoeve, M. E. Rodriguez, M. Säflund, V. Michel, L. Magimel, A. Ripoll, T. Yu, M.-A. Hakimi, J. P. Saeij, D. M. Ozata, A. Barragan
This study identifies how Toxoplasma gondii uses GRA effectors to manipulate host signaling and chromatin accessibility, promoting macrophage migration and parasite dissemination.
bioRxiv · Feb 6, 2024 · PreprintMicrobiology