M.-A. Hakimi

Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination

This study identifies how Toxoplasma gondii uses GRA effectors to manipulate host signaling and chromatin accessibility, promoting macrophage migration and parasite dissemination.

Toxoplasma gondii F-Box Protein L2 Silences Feline-Restricted Genes Necessary for Sexual Commitment

This paper identifies TgFBXL2, an F-box protein in Toxoplasma gondii, which represses feline-restricted genes required for sexual commitment by modulating SCF-E3 ubiquitin ligase activity.

In vitro production of cat-restricted Toxoplasma pre-sexual stages by epigenetic reprogramming

This study shows that AP2XII-1 and AP2XI-2 transcription factors reprogram Toxoplasma gondii tachyzoites to merozoites in vitro, enabling the production of pre-sexual stages without using cats.

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

This paper identifies altiratinib as a selective inhibitor of PRP4K/CLK3 kinases in apicomplexan parasites, showing broad-spectrum antiparasitic activity against toxoplasmosis and malaria.

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental genes partitioning in Toxoplasma

This paper identifies an m6A-dependent polyadenylation mechanism in Toxoplasma gondii that prevents transcriptional read-through and maintains transcriptome integrity, similar to a plant mechanism.

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodelling

This study shows that apicomplexan parasites adapt to host nutritional changes by shifting lipid acquisition between de novo synthesis and host scavenging, involving apicoplast lipid metabolism and host organelle remodeling.