Cell division history determines hematopoietic stem cell potency
F. Arai, P. S. Stumpf, Y. M. Ikushima, K. Hosokawa, A. Roch, M. P. Lutolf, T. Suda, B. D. MacArthur
This study uses single-cell profiling and deep learning to show that hematopoietic stem cell self-renewal declines with age due to stochastic division patterns and prior division history.
bioRxiv · Jan 15, 2019 · PreprintCell Biology