Author

M. P. Lutolf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4 Cancer Biology· 2 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 6 Organism:human· 6 Assay:scRNA-seq· 3 Research Focus:cell-cell communication· 2 Approach:deep learning· 2 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

N. Brandenberg· 3 shared N. Broguiere· 3 shared D. Dutta· 2 shared F. Rivest· 2 shared G. Coukos· 2 shared K. Homicsko· 2 shared M. Hofer· 2 shared S. Hoehnel· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

N. Brandenberg

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A Bioengineered Platform for Enhanced Observability of Patterned Gastrointestinal Organoid Monolayers with Bilateral Access

M. Hofer, M. A. Duque-Correa, M. P. Lutolf

This paper introduces a bioengineered platform for bilaterally accessible GI organoid monolayers, enabling improved observability and studies of epithelial dynamics and pathogen interactions.

bioRxiv · Jan 26, 2024 · PreprintBioengineering

Dissection and reconstruction of the colorectal cancer tumor microenvironment

N. Broguiere, L. F. Lorenzo-Martin, S. Ragusa, F. Rivest, N. Brandenberg, S. Hohnel, D. Dutta, M. Gueye, D. Alpern, B. Deplancke, L. Kandalaft, G. Coukos, K. Homicsko, M. P. Lutolf

This study reconstructs the colorectal cancer tumor microenvironment using patient-derived organoids and co-cultures, revealing how stromal cells influence cancer behavior and immune evasion.

bioRxiv · Nov 1, 2023 · PreprintCancer Biology

Bioengineered human colon organoids with in vivo-like complexity and function

O. Mitrofanova, N. Broguiere, M. Nikolaev, M. P. Lutolf

This paper develops bioengineered human colon organoids that mimic in vivo complexity and function, enabling long-term study of gut physiology and disease.

bioRxiv · Oct 5, 2023 · PreprintBioengineering

OpenSIM: open source microscope add-on for structured illumination microscopy

M. T. M. Hannebelle, E. Raeth, S. Leitao, T. Lukes, J. Pospisil, C. Toniolo, O. F. Venzin, A. Chrisnandy, P. P. Swain, N. Ronceray, M. P. Lutolf, A. C. Oates, G. M. Hagen, T. Lasser, A. Radenovic, , G. E. Fantner

The paper introduces openSIM, an open-hardware add-on that upgrades existing microscopes to structured illumination microscopy (SIM) for super-resolution imaging.

bioRxiv · Jun 16, 2023 · PreprintBioengineering

Primate-specific cis- and trans-regulators shape transcriptional networks during human development

J. Pontis, D. Trono, C. Pulver, E. Planet, D. Grun, S. Offner, J. Duc, A. Manfrin, M. P. Lutolf

The paper identifies primate-specific transposable elements and their regulatory factors that influence transcriptional networks during human development.

bioRxiv · Aug 18, 2021 · PreprintEvolutionary Biology

Microarrayed human bone marrow organoids for modeling blood stem cell dynamics

S. Giger, M. Hofer, M. Miljkovic-Licina, S. Hoehnel, N. Brandenberg, R. Guiet, M. Ehrbar, E. Kleiner, K. Gegenschatz, T. Matthes, M. P. Lutolf

This paper develops a 3D bone marrow organoid model to study blood stem cell dynamics and drug responses in leukemia.

bioRxiv · May 26, 2021Bioengineering

Probing the killing potency of tumor-infiltrating lymphocytes on microarrayed autologous tumoroids

D. Dutta, F. Rivest, F. Lorenzo Martin, N. Broguiere, L. Tillard, S. Ragusa, N. Brandenberg, S. Hoehnel, D. Saugy, S. Rusakiewicz, K. Homicsko, G. Coukos, M. P. Lutolf

This paper develops a microarray-based assay to assess tumor-infiltrating lymphocyte (TIL) activity against autologous tumoroids, identifying responders to immunotherapy.

bioRxiv · Mar 30, 2021 · PreprintCancer Biology

Cell division history determines hematopoietic stem cell potency

F. Arai, P. S. Stumpf, Y. M. Ikushima, K. Hosokawa, A. Roch, M. P. Lutolf, T. Suda, B. D. MacArthur

This study uses single-cell profiling and deep learning to show that hematopoietic stem cell self-renewal declines with age due to stochastic division patterns and prior division history.

bioRxiv · Jan 15, 2019 · PreprintCell Biology