Author

F. Arai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:clustering· 2 Approach:deep learning· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

B. D. MacArthur· 2 shared P. S. Stumpf· 2 shared A. Iwama· 1 shared A. Okinaga· 1 shared A. Roch· 1 shared A. Saraya· 1 shared C. Hu· 1 shared C. Zhang· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCell Biology

B. D. MacArthur

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Author profile →

5 papers

Recent·Most cited

Flow zoometry of Drosophila

W. Peterson, J. Arenson, S. Hata, L. Kacenauskaite, T. Kobayashi, T. Otsuka, H. Wang, Y. Wada, K. Hiramatsu, Z. He, J.-E. Clement, C. Zhang, C. Hu, P. McCann, H. Kanazawa, , K. Goda

This paper introduces flow zoometry, a high-throughput screening method for Drosophila, enabling rapid, automated, and high-resolution analysis of whole animals.

bioRxiv · Apr 4, 2024 · PreprintBioengineering

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

Y. Nakajima-Takagi, M. Oshima, J. Takano, S. Koide, N. Itokawa, S. Uemura, M. Yamashita, S. Andoh, K. Aoyama, Y. Isshiki, D. Shinoda, A. Saraya, F. Arai, K. Yamaguchi, Y. Furukawa, , A. Iwama

This study identifies PRC1.1 as a regulator of homeostatic and emergency myelopoiesis, showing its role in balancing myeloid differentiation and preventing transformation.

bioRxiv · Sep 7, 2022Immunology

Heterogeneity and 'memory in stem cell populations

P. S. Stumpf, F. Arai, B. D. MacArthur

The paper proposes that cellular memories explain heterogeneity in stem cell populations and how this relates to changes in stem cell numbers and regenerative potency over time.

bioRxiv · Sep 22, 2020Cell Biology

Cell division history determines hematopoietic stem cell potency

F. Arai, P. S. Stumpf, Y. M. Ikushima, K. Hosokawa, A. Roch, M. P. Lutolf, T. Suda, B. D. MacArthur

This study uses single-cell profiling and deep learning to show that hematopoietic stem cell self-renewal declines with age due to stochastic division patterns and prior division history.

bioRxiv · Jan 15, 2019 · PreprintCell Biology

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

H. Kobayashi, T. Morikawa, A. Okinaga, F. Hamano, T. Hashidate-Yoshida, S. Watanuki, D. Hishikawa, H. Shindou, F. Arai, Y. Kabe, M. Suematsu, T. Shimizu, K. Takubo

This study maintains engraftable quiescent HSCs in culture for 1 month using low cytokines, hypoxia, and high fatty acids.

bioRxiv · Dec 6, 2018Cell Biology