Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling
T. Wang, S. Young, F. Tuettelmann, A. Roepke, C. Krallmann, S. Kliesch, X.-H. Zeng, C. Brenker, T. Struenker
This study investigates whether CatSper channels in human sperm are activated by cAMP and PKA signaling, finding that cAMP analogs activate them extracellularly and PKA inhibitors act off-target.
bioRxiv · Feb 10, 2020Cell Biology