T. Wang

Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

This study identifies glucokinase (GCK) as a metabolic enzyme that regulates lineage plasticity in neuroendocrine prostate cancer through its interaction with AKT1.

Phase Behavior of TDP-43 and hnRNP H1: From Soluble and Aggregated States to Liquid-Like Droplets

This study investigates the phase behavior of TDP-43 and hnRNP H1, revealing an aggregate-to-droplet transition and domain matching in phase separation of LCD-containing proteins.

IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming

This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

Podoplanin Positive Cell-derived Extracellular Vesicles Contribute to Cardiac Amyloidosis After Myocardial Infarction

This study identifies that Podoplanin-expressing mesenchymal stromal cells release exosomes that trigger SAA3 overproduction in macrophages, leading to cardiac amyloidosis after myocardial infarction.

Cmai: Predicting Antigen-Antibody Interactions from Massive Sequencing Data

Cmai predicts antigen-antibody interactions from high-throughput BCR sequencing data, revealing immune responses to tumor antigens and ICI treatment outcomes.

A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions

The paper identifies CNBP as a factor required for mRNA localization to cell protrusions by forming a motor-adaptor complex with KIF1C.

A detailed analysis of 16S rRNA gene sequencing and conventional PCR-based testing for the diagnosis of bacterial pathogens and discovery of novel bacteria

This study compares 16S rRNA gene sequencing and conventional PCR for diagnosing bacterial pathogens in chickens with swollen head syndrome, finding that sequencing is more reliable and can detect novel bacteria.

Increased pathogenicity and transmission of SARS-CoV-2 Omicron XBB.1.9 sublineage, including HK.3 and EG.5.1

This study investigates the virological features of SARS-CoV-2 Omicron XBB.1.9 subvariants, finding increased pathogenicity and transmissibility in HK.3 and EG.5.1 compared to previous variants.

Biochemical characterization of extended-spectrum β-lactamases from Akkermansia genus

The paper characterizes β-lactamases from Akkermansia species, showing they exhibit extended-spectrum activity and lack transferable resistance genes.

An expanded metabolic pathway for androgen production by host-associated bacteria

This study identifies a bacterial pathway for androgen production, showing that gut and urinary bacteria can convert androstenedione to epitestosterone and testosterone, which promote prostate cancer growth.

Higher-Order Interactions in Auxotroph Communities Enhance Their Resilience to Resource Fluctuations

This study introduces a consumer-resource model to analyze higher-order interactions in auxotroph communities and shows how these interactions enhance resilience to resource fluctuations.

Characterizing interactions of ER resident proteins in situ through the YST-PPI method

The paper introduces YST-PPI, a method to study ER resident protein interactions in situ, identifies 74 protein pairs, and highlights Lhs1p's role in regulating these interactions.

A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

This study evaluates an insect-based chimeric virus vaccine against Chikungunya fever, showing rapid and durable protection in macaques.

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4'-CN-4-Aza-7,9-Dideazaadenosine C-Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys.

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

Mechanical stress through growth on stiffer substrates impacts animal health and longevity in C. elegans.

This study investigates the impact of substrate stiffness on C. elegans health and longevity, finding only mild effects on cellular and organismal health.

In vivo Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies

This study develops HALA antibodies that adjust ADC delivery based on tumor HER2 expression, improving efficacy across varying expression levels in preclinical models.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Functional Redundancy in Candida auris Cell Surface Adhesins Crucial for Cell-Cell Interaction and Aggregation

The paper identifies Als5 and Scf1 as complementary adhesins in Candida auris that promote cell-cell interaction and biofilm formation through functional redundancy.

Physical forces drive C. elegans embryonic deformation

The paper investigates how physical forces from actomyosin networks and muscles drive C. elegans embryonic elongation and bending during development.

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

A new group of LysM-RLKs involved in symbiotic signal perception and arbuscular mycorrhiza establishment

The paper identifies a new group of LysM-RLK receptors that bind both LCO and CO, playing a complementary role with LYR-IA receptors in arbuscular mycorrhiza formation.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

Assessment of the Histone Mark-based Epigenomic Landscape in Human Myometrium at Term Pregnancy

This study maps the epigenomic landscape of human myometrium at term pregnancy, identifying enhancers and regulatory elements associated with PGR and PLCL2.

Molecular Architecture of Chitin and Chitosan-Dominated Cell Walls in Zygomycetous Fungal Pathogens by Solid-State NMR

This study uses solid-state NMR to analyze the molecular structure of cell walls in Mucorales fungi, revealing the composition and organization of chitin, chitosan, and associated polysaccharides.

Architecture of the spinach plastid-encoded RNA polymerase

This study presents the cryo-EM structure of the spinach plastid-encoded RNA polymerase complex, revealing its composition and spatial arrangement of subunits and associated proteins.

Proteomic analysis uncovers clusterin-mediated disruption of actin-based contractile machinery in the trabecular meshwork to lower intraocular pressure

This study identifies clusterin's role in lowering intraocular pressure by modulating actin-based contractile machinery and ECM balance in trabecular meshwork cells.

Regulatory role of cholesterol in modulating actin dynamics and cell adhesive interactions in the trabecular meshwork

This study investigates how cholesterol affects actin dynamics and cell adhesion in trabecular meshwork cells, showing that cholesterol modulates PIP2 levels and integrin distribution, thereby influencing cell stiffness and intraocular pressure.

SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing

The study identifies SKSR1 as a key virulence factor in Cryptosporidium by crossing isolates with different virulence and analyzing genetic loci associated with infectivity.