S. Young

T cell cholesterol transport is a metabolic checkpoint that links intestinal immune responses to dietary lipid absorption

This study identifies Aster-A as a cholesterol transporter in T cells that regulates immune signaling and metabolic responses by controlling membrane cholesterol levels.

Pharmacogenomic discovery of genetically targeted cancer therapies optimized against clinical outcomes

The paper identifies pharmacogenomic screening principles that predict clinical efficacy in cancer patients with specific driver mutations.

Durable immunity to SARS-CoV-2 in both lower and upper airways achieved with a gorilla adenovirus (GRAd) S-2P vaccine in non-human primates

This study shows a gorilla adenovirus-based vaccine provides durable immunity against SARS-CoV-2 in both airways of non-human primates, with enhanced protection from aerosol delivery and prime-boost regimens.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Synergistic effects of inhibitors targeting PI3K and Aurora Kinase A in preclinical inflammatory breast cancer models

This study shows that combining PI3K and AURKA inhibitors synergistically kills IBC cells and reduces tumor growth and metastasis in xenograft models.

Meta-analysis of macrophage nanoparticle targeting across blood and solid tumors using an eLDA Topic modeling Machine Learning approach

This study uses topic modeling to analyze nanoparticle targeting of macrophages in tumors over 20 years, identifying 6 topics and trends in nanoparticle usage and therapeutic strategies.

Multi-site Performance Evaluation of the cobas 5800 System and Comparison to the cobas 6800/8800 Systems for Quantitative Measurement of HBV, HCV, and HIV-1 Viral Load.

This study compares the performance of the cobas 5800 system to the cobas 6800/8800 systems for viral load measurement of HBV, HCV, and HIV-1 across multiple sites, finding high correlation and acceptable variability.

G-Trap Assay I: Small GTPases as sensitive immune response biomarkers for active bacteremia

This study uses a novel G-Trap assay to detect GTPase activation in trauma patients, showing it correlates with infection-induced immune activation and antibiotic treatment effects.

G-Trap Assay II: Characterization of blood Leukocyte Functionality differentiates immune activation and immune suppression in bacteremia patient samples

The paper measures Rac1*GTP in blood leukocytes from sepsis patients and controls to differentiate immune activation from suppression, identifying elevated levels in infected patients.

MRI Guided Fresh Tissue Procurement in Radical Prostatectomy Specimens: An Evolutionary Paradigm

This paper evaluates new methods for precise fresh tissue sampling in prostate specimens using 3D-printed molds, showing improved accuracy over traditional surgical estimation.

Extracellular vesicles secreted by Brugia malayi microfilariae modulate the melanization pathway in the mosquito host

This paper shows that extracellular vesicles from Brugia malayi microfilariae reduce melanization in Aedes aegypti mosquitoes by downregulating AAEL002590 and decreasing phenoloxidase activity.

Shedding light on the control of CatSper Ca2+ channels by cAMP and chemicals used to probe cAMP signaling

This study investigates whether CatSper channels in human sperm are activated by cAMP and PKA signaling, finding that cAMP analogs activate them extracellularly and PKA inhibitors act off-target.

A meta-analysis reveals temperature, dose, life stage, and taxonomy influence host susceptibility to a fungal parasite

This study meta-analyzes 58 amphibian-Bd infection experiments to show temperature, dose, life stage, and taxonomy influence host mortality.

Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

Genomic Analysis of Emerging Florfenicol-Resistant Campylobacter coli Isolated from the Intestinal Cecal Contents of Cattle in the United States

This study identifies a conjugative MDR plasmid carrying the cfr(C) gene in florfenicol-resistant Campylobacter coli from cattle, conferring resistance to multiple antimicrobials including linezolid.

Transmission of human-associated microbiota along family and social networks

The paper examines bacterial transmission in gut and oral microbiomes of a closed cohort in Fiji, finding weak but significant transmission within households and between spouses using strain-level data.

Impacts of thermal mismatches on chytrid fungus Batrachochytrium dendrobatidis prevalence are moderated by life stage, body size, elevation and latitude

The paper examines how thermal mismatches affect Bd infection prevalence in amphibians, finding that larger hosts and lower-latitude hosts are more susceptible under temperature mismatches.

Validation of a low-cost, carbon dioxide-based cryoablation system for percutaneous tumor ablation

This paper validates a low-cost cryoablation system using carbon dioxide for tumor ablation in resource-constrained settings, showing effective necrosis in rat and porcine models.

Aberrant mast cell activation promotes chronic recurrent multifocal osteomyelitis

This study identifies mast cells as contributors to bone inflammation in CMO/CRMO by showing their accumulation in inflamed tissues and elevated mast cell markers in CRMO patients.