A. Rubio

In vitro activity and in vivo efficacy against non-tuberculous mycobacteria of SPR719, the active moiety of the novel oral benzimidazole prodrug SPR720

This study evaluates the in vitro activity and in vivo efficacy of SPR720 against non-tuberculous mycobacteria, showing promising results in murine models.

L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation

This study shows L-arginine improves autophagy defects in GM2 gangliosidoses by restoring mTOR signaling and reducing lysosomal permeability in patient fibroblasts.

Reconstitution of intestinal stem cell niche in vitro with pharmacological inhibitors or L-WRN conditioned medium differentially regulates epithelial proliferation, differentiation and barrier function in rabbit caecum organoids

This paper compares the effects of 2Ki medium and L-WRN conditioned medium on rabbit caecum organoids, showing differential regulation of proliferation, differentiation, and barrier function.

Morphological profiling of human T and NK lymphocytes identifies actin-mediated control of the immunological synapse

This study uses morphological profiling to identify actin-mediated control of the immunological synapse in human T and NK lymphocytes, revealing inter-individual heterogeneity and defects in ARPC1B-mutated CD8+ T cells.

BEE AND FLOWERING PLANT COMMUNITIES IN A RIPARIAN CORRIDOR OF THE LOWER RIO GRANDE RIVER (TEXAS, USA)

The paper samples bee and flowering plant communities in a riparian corridor, finding seasonal richness peaks and key species driving community patterns.