A. Sanz

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype

This study shows that NLRP1 inflammasome promotes senescence and SASP through GSDMD-dependent regulation of p16, p21, p53, and SASP expression.

ROS signalling requires uninterrupted electron flow and is lost during ageing in flies

The paper shows that ROS-RET signalling requires uninterrupted electron flow through the ETC and is lost during ageing in flies, leading to persistent mtROS production and reduced stress adaptation.

L-arginine ameliorates defective autophagy in GM2 gangliosidoses by mTOR modulation

This study shows L-arginine improves autophagy defects in GM2 gangliosidoses by restoring mTOR signaling and reducing lysosomal permeability in patient fibroblasts.

Inhibition of the NLRP3 inflammasome prevents ovarian aging

This study shows that inhibiting the NLRP3 inflammasome improves ovarian function and fertility in aging mice by enhancing AMH, autophagy, and reducing FSH and estradiol levels.

Calcitriol increases frataxin levels and restores altered markers in cell models of Friedreich Ataxia

Autophagy promotes cell and organismal survival by maintaining NAD(H) pools

This study identifies autophagy's role in maintaining NAD(H) pools, showing that NAD(H) depletion leads to cell death and that NAD(H) supplementation can reverse this effect in autophagy-deficient models.