Peripheral tolerance to insulin is encoded by mimicry in the microbiome
A. Rubio Garcia, A. Paterou, M. Lee, H. Slawinski, L. S. Wicker, J. A. Todd, M. L. Pekalski
The paper identifies microbial mimicry of insulin epitopes in the gut microbiome as a potential cause of type 1 diabetes by showing that transketolase mimotopes trigger immune responses similar to insulin.
bioRxiv · Dec 18, 2019 · PreprintImmunology