M. Lee

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases

The paper reconstructs the protein interactome of the Last Eukaryotic Common Ancestor and identifies new human gene-disease associations for bone density and congenital birth defects.

Evolutionary Systems Biology Identifies Genetic Trade-offs In Rice Defense Against Above- and Belowground Attackers

The paper identifies genetic trade-offs in rice defense against above- and belowground attackers through analysis of KSL8 and MG1 loci.

The role of YAP/TAZ signaling in dendritic cell-mediated pathogenesis of insulin resistance and non-alcoholic fatty liver disease

This study investigates the role of YAP/TAZ in dendritic cell-mediated pathogenesis of insulin resistance and NAFLD using a high-fat diet model, finding minimal impact on disease progression.

Vaccine-elicited and naturally elicited antibodies differ in their recognition of the HIV-1 fusion peptide

This study compares vaccine-elicited and naturally elicited antibodies' recognition of HIV-1 fusion peptide sequences, finding that naturally elicited antibodies show greater tolerance to sequence variation.

Mechanical Rejuvenation of Mesenchymal Stem Cells from Aged Patients

This study shows that mechanical conditioning improves the regenerative potential of aged mesenchymal stem cells by reducing senescence and altering their genetic landscape.

Characterization of Viroplasm-Like Structures by Co-Expression of NSP5 and NSP2 Across Rotavirus Species A to J

This study examines the formation of viroplasm-like structures (VLS) by co-expressing NSP5 and NSP2 across Rotavirus species A-J, finding species-specific VLS morphology and self-oligomerization properties of NSP5.

Participatory science methods to monitor water quality and ground truth remote sensing of the Chesapeake Bay

The paper describes participatory science methods for monitoring water quality in the Chesapeake Bay using volunteer scientists and remote sensing to improve data collection and algorithm development.

Realigning representational drift in mouse visual cortex by flexible brain-machine interfaces

This study uses flexible electrodes to track and model representational drift in mouse visual cortex, enabling a stable decoder for brain-machine interfaces.

Structural Determinants of Vibrio cholerae FeoB Nucleotide Promiscuity

This study identifies structural determinants of FeoB nucleotide promiscuity in Vibrio cholerae by analyzing crystal structures and thermodynamics.

Quinoxaline-Based Anti-Schistosomal Compounds Have Potent Anti-Malarial Activity

This study identifies quinoxaline-based anti-schistosomal compounds with potent anti-malarial activity against Plasmodium falciparum, including resistance mechanisms involving pfqrp1 and pfatp2.

The influence of environment on mosquito feeding patterns: a meta-analysis of "universal" DNA diet studies in a global context

This study analyzes global blood-meal patterns of six mosquito species using universal DNA methods, finding environmental factors influence host selection beyond host availability.

The T-cell niche tunes immune function through modulation of the cytoskeleton and TCR-antigen forces

This study shows that the adipocyte niche impairs T-cell function by modulating cytoskeletal dynamics and reducing TCR-antigen forces in both mice and human T-cells.

Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells

The paper uses scRNA-seq to analyze the antiviral response in human dendritic cells infected with ZIKV, identifying a network of host genes and proteins involved in antiviral defense.

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

Heterozygous Kmt2d loss diminishes enhancers to render medulloblastoma cells vulnerable to combinatory inhibition of lysine demethylation and oxidative phosphorylation

This study shows that heterozygous Kmt2d loss promotes medulloblastoma by enhancing tumor-promoting programs and that combining LSD1 inhibition with oxidative phosphorylation blockade reduces tumorigenicity.

Increased epithelial mTORC1 activity in chronic rhinosinusitis with nasal polyps

The paper identifies increased mTORC1 activity in CRSwNP epithelial cells and links it to cytokine production and inflammation in both CRSwNP and asthma.

MMPs and NETs are detrimental in human CNS-tuberculosis and MMP inhibition in a mouse model improves survival

The paper identifies elevated MMPs and NETs in CNS-TB patients and shows MMP inhibition improves survival in a mouse model.

Functional immune state classification of unlabeled live human monocytes using holotomography and machine learning

This study uses holotomography and machine learning to classify functional immune states of human monocytes, achieving high accuracy in identifying hyper-inflammatory and immune-suppressed states.

Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose

This paper identifies a novel bacterial pathway for sulfofucose catabolism in Paracoccus wurundjeri, involving a sulfofucolytic Entner-Doudoroff pathway and subsequent biomineralization to sulfite.

In vivo single-cell CRISPR uncovers distinct TNF-alphaprograms in clonal expansion and tumorigenesis

This study uses in vivo single-cell CRISPR to identify distinct TNF-α programs in clonal expansion and tumorigenesis, showing their roles in epithelial transformation and tumor initiation.

Hybrid machine-learning framework for volumetric segmentation and quantification of vacuoles in individual unlabeled yeast cells using holotomography

This paper develops a hybrid machine-learning framework to segment and quantify vacuoles in unlabeled yeast cells using holotomography data.

DNA repair and anti-cancer mechanisms in the longest-living mammal: the bowhead whale

This study investigates DNA repair mechanisms in bowhead whales, showing their high efficiency and accuracy in repairing DNA damage, which may explain their long lifespan without cancer.

Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys

Spatiotemporal Genomic Profiling of Intestinal Metaplasia Reveals Clonal Dynamics of Gastric Cancer Progression

This study analyzes genomic and transcriptomic data from gastric samples to identify driver genes and clonal dynamics in intestinal metaplasia, showing their progression to gastric cancer and the role of microbial dysbiosis.

Molecular basis of sulfolactate synthesis by sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum

This paper reports the cryo-EM structure and kinetics of sulfolactaldehyde dehydrogenase from Rhizobium leguminosarum, revealing its cofactor usage and catalytic mechanism in sulfolactate synthesis.

STORM imaging buffer with refractive index matched to standard immersion oil

This paper introduces a STORM imaging buffer with refractive index matched to standard immersion oil, improving imaging depth and resolution for thick tissues.

Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells

This study shows that losartan, an angiotensin II receptor inhibitor, reduces liver fibrosis and enhances T cell infiltration in HCC, improving response to PD-1 blockade.

A pillar/perfusion plate enhances cell growth, reproducibility, throughput, and user friendliness in dynamic 3D cell culture

The paper introduces a pillar/perfusion plate for dynamic 3D cell culture, improving growth, reproducibility, throughput, and user friendliness compared to static methods.

High-resolution assessment of multidimensional cellular mechanics using label-free refractive-index traction force microscopy

This paper introduces RI-TFM, a high-speed label-free technique for 3D cellular mechanics, and demonstrates its ability to measure traction forces and morphology in cells.

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.