Parallel clonal and molecular profiling of hematopoietic stem cells using RNA barcoding
E. E. Wojtowicz, J. Mistry, V. Uzun, A. Scoones, D. V. Chin, L. Kettyle, F. Grasso, A. M. Lord, G. Etherington, C. Hellmich, P. S. Woll, M. E. Belderbos, K. M. Bowles, C. Nerlov, W. Haerty, , I. C. Macaulay
This study uses RNA barcoding and single-cell RNA-seq to analyze clonal dynamics of hematopoietic stem cells, showing that platelet depletion shifts HSC output to platelets and new myeloid clones.
bioRxiv · May 16, 2022 · PreprintCell Biology