C. Nerlov

Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging

This study identifies how DNMT3A and TET2 mutations in hematopoietic stem cells confer a selective advantage by reducing inflammation and aging effects.

Slow integrin-dependent migration organizes networks of tissue-resident mast cells

This study shows that mast cells use slow integrin-dependent migration to form tissue networks, differing from other leukocytes that use fast adhesion-free movement.

Plasmacytoid dendritic cells regulate megakaryocyte and platelet homeostasis

This study identifies plasmacytoid dendritic cells (pDCs) as regulators of megakaryopoiesis and platelet homeostasis, showing their role in maintaining steady-state and stress conditions, and their involvement in SARS-CoV2-induced thrombosis.

Parallel clonal and molecular profiling of hematopoietic stem cells using RNA barcoding

This study uses RNA barcoding and single-cell RNA-seq to analyze clonal dynamics of hematopoietic stem cells, showing that platelet depletion shifts HSC output to platelets and new myeloid clones.

Identification and Age-dependent Increase of Platelet Biased Human Hematopoietic Stem Cells

The paper identifies platelet-biased human hematopoietic stem cells (HSCs) and shows their proportion and transcriptional platelet priming increase with age.

Myeloid-biased HSC require Semaphorin 4A from the bone marrow niche for self-renewal under stress and life-long persistence

This study identifies Sema4A as a critical niche factor required for myeloid-biased HSC self-renewal and long-term persistence under stress.

Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia

The paper identifies mutation synergy between CSF3R and CEBPA in AML, showing their interaction at myeloid lineage enhancers and the requirement of CEBPA mutations as an initial event.