Slow conformational exchange and overall rocking motion in ubiquitin protein crystals
V. Kurauskas, S. A. Izmailov, O. N. Rogacheva, A. Hessel, I. Ayala, J. Woodhouse, A. Shilova, Y. Xue, T. Yuwen, N. Coquelle, J.-P. Colletier, N. R. Skrynnikov, P. Schanda
This study investigates how crystal packing affects microsecond dynamics of ubiquitin using solid-state NMR and MD simulations, revealing altered thermodynamics and kinetics of conformational exchange.
bioRxiv · Jun 2, 2017Biophysics