Novel features in the structure of P-glycoprotein (ABCB1) in the post-hydrolytic state as determined at 7.9A resolution
N. Thongin, R. F. Collins, A. Barbieri, T. Shafi, A. Siebert, R. C. Ford
This study reports novel structural features of P-glycoprotein in the post-hydrolytic state using cryo-EM at 7.9Å resolution, revealing conformational changes and implications for drug transport and resistance.
bioRxiv · Apr 25, 2018Biochemistry