Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth
A. S. Krall, P. J. Mullen, F. Surjono, M. Momcilovic, E. W. Schmid, C. J. Halbrook, A. Thambundit, S. D. Mittelman, C. A. Lyssiotis, D. B. Shackelford, S. R. Knott, H. R. Christofk
This study shows that asparagine, derived from mitochondrial respiration, supports mTORC1 activity and tumor growth, and that targeting asparagine synthesis or consumption can impair tumor growth.
bioRxiv · Mar 17, 2020 · PreprintCancer Biology