CALR frameshift mutations in MPN patient-derived iPS cells accelerate maturation of megakaryocytes
K. Olschok, L. Han, M. A. S. de Toledo, J. Boehnke, M. Grasshoff, I. G. Costa, A. Theocharides, A. Maurer, H. M. Schueler, E. M. Buhl, K. Pannen, J. Baumeister, M. Kalmer, S. Gupta, P. Boor, , S. Koschmieder
This study shows CALR mutations in iPS cells from MPN patients accelerate megakaryocyte maturation and identify hypoxia signaling as a therapeutic target.
Stem Cell Reports · Nov 1, 2021Peer-reviewedCancer Biology