Author

S. Koschmieder

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

M. Zenke· 3 shared N. Chatain· 3 shared T. H. Bruemmendorf· 3 shared A. Maurer· 2 shared H. M. Schueler· 2 shared J. Boehnke· 2 shared K. Olschok· 2 shared M. A. Szymanski de Toledo· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersCancer Biology

M. Zenke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms

R.-M. Koerber, C. Krollmann, K. Cieslak, E. Tregel, T. H. Brümmendorf, S. Koschmieder, M. Griesshammer, I. Gütgemann, P. Brossart, R. Skoda, C. C. Kolbe, E. Latz, D. Wolf, L. L. Teichmann

This study shows that NLRP3 inflammasome activation drives JAK2V617F mutant myeloproliferative neoplasms by promoting inflammation, platelet production, and fibrosis, and that its inhibition can reverse disease features.

bioRxiv · Mar 9, 2024Cancer Biology

CALR frameshift mutations in MPN patient-derived iPS cells accelerate maturation of megakaryocytes

K. Olschok, L. Han, M. A. S. de Toledo, J. Boehnke, M. Grasshoff, I. G. Costa, A. Theocharides, A. Maurer, H. M. Schueler, E. M. Buhl, K. Pannen, J. Baumeister, M. Kalmer, S. Gupta, P. Boor, , S. Koschmieder

This study shows CALR mutations in iPS cells from MPN patients accelerate megakaryocyte maturation and identify hypoxia signaling as a therapeutic target.

Stem Cell Reports · Nov 1, 2021Peer-reviewedCancer Biology

Human DC3 Antigen Presenting Dendritic Cells from Induced Pluripotent Stem Cells

T. Satoh, M. A. Szymanski de Toledo, J. Boehnke, K. Olschok, N. Flosdorf, K. Goetz, C. Kuestermann, S. Sontag, K. Sere, S. Koschmieder, T. H. Bruemmendorf, N. Chatain, Y.-i. Tagawa, M. Zenke

This paper describes the generation of human DC3 antigen-presenting cells from induced pluripotent stem cells and examines the effect of JAK2 V617F mutations on their differentiation.

bioRxiv · Jun 22, 2021Immunology

Nintedanib Targets KIT D816V Neoplastic Cells Derived from Induced Pluripotent Stem cells of Systemic Mastocytosis

M. A. Szymanski de Toledo, M. Gatz, S. Sontag, K. V. Gleixer, G. Eisenwort, K. Feldberg, F. Kluge, R. Guareschi, G. Rossetti, A. S. Sechi, O. Dufva, S. M. Mustjoki, A. Maurer, H. M. Schueler, R. Goetzke, , M. Zenke

This study identifies nintedanib as a novel KIT D816V inhibitor effective against patient-derived neoplastic mast cells in systemic mastocytosis.

bioRxiv · May 6, 2020Cancer Biology