INSULIN GROWTH FACTOR I AND ITS RECEPTOR ARE ANTAGONISTIC MODULATORS OF GLUCOSE HANDLING BY ASTROCYTES
E. Hernandez-Garzón, A.M. Fernandez, A. Perez-Alvarez, S. Mederos, P. Perez-Domper, P. Bascuñana, R.F. de la Rosa, M. Delgado, M.A. Pozo, A. Miranda-Vizuete, D. Guerrero-Gomez, E. Moreno, P.J. McCormick, A. Santi, L. Genis, , I. Torres Aleman
The paper shows that unliganded IGF-IR inhibits astrocyte glucose uptake while IGF-I and insulin synergistically enhance it through MAPK/PKD and Rac1/GIPC1 pathways.
bioRxiv · Jul 31, 2015 · PreprintNeuroscience