Cancer BiologybioRxiv
Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin
F. J. Garcia-Rodriguez, C. Martinez-Fernandez, D. Brena…·J. Ceron
This study investigates cisplatin sensitivity in C. elegans, identifying factors like DAF-16/FOXO, SKN-1/Nrf2, and the intrinsic apoptotic pathway, and discovers a resistance mechanism involving trxr-1 and selenocysteine.
DOI 10.1242/dmm.033506