Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza
A. Ohno, N. Maita, T. Tabata, H. Nagano, K. Arita, M. Ariyoshi, T. Uchida, R. Nakao, A. Ulla, K. Sugiura, K. Kishimoto, S. Teshima-Kondo, Y. Okumura, T. Nikawa
The paper determines the crystal structure of human MSPL bound to an inhibitor, revealing key residues involved in substrate recognition and providing a homology model for TMPRSS2.
bioRxiv · Jun 12, 2020Biophysics