Leukemic cell-secreted interleukin-9 suppresses cytotoxic T cell-mediated killing in chronic lymphocytic leukemia
G. Boncompagni, V. Tatangelo, L. Lopresti, C. Ulivieri, N. Capitani, C. Tangredi, F. Finetti, G. Marotta, F. Frezzato, A. Visentin, S. Ciofini, A. Gozzetti, M. Bocchia, D. Calzada-Fraile, N. B. Martin Cofreces, , C. T. Baldari
This study shows that IL-9 secreted by leukemic cells suppresses CTL-mediated killing in CLL by increasing PD-1 expression and impairing immune synapse formation.
bioRxiv · Oct 23, 2023 · PreprintCancer Biology