Surface versus volume synthesis governs growth-dependent efficacy of a β-lactam antibiotic
R. Brouwers, L. Mancini, S. Tavaddod, J. Biboy, M. Mauri, E. Tatham, M.-L. Enghardt, A. Zander, P. Cicuta, W. Vollmer, R. Allen
This study shows that mecillinam affects the balance between surface area and volume synthesis in E. coli, leading to growth-rate dependent efficacy and lysis or sustained growth depending on the medium.
bioRxiv · Jan 31, 2024 · PreprintMicrobiology