Structural and Computational Design of a SARS-CoV-2 Spike Antigen with Increased Receptor Binding Domain Exposure and Improved Immunogenicity
J. Williams, M. Biancucci, L. Lessen, S. Tian, A. Balsaraf, L. Chen, C. Chesterman, G. Maruggi, S. Vandepaer, Y. Huang, C. Mallett, A.-M. Steff, M. Bottomley, E. Malito, N. Wahome, W. Harshbarger
This study designs a modified SARS-CoV-2 Spike antigen with increased RBD exposure and immunogenicity, showing improved neutralizing antibody responses in mice.
bioRxiv · Nov 29, 2022 · PreprintImmunology