J. Williams

Classification of Variants of Reduced Penetrance in High Penetrance Cancer Susceptibility Genes: Framework for Genetics Clinicians and Clinical Scientists by CanVIG-UK (Cancer Variant Interpretation Group-UK)

The paper develops a framework for classifying variants of reduced penetrance in cancer susceptibility genes to improve variant interpretation consistency.

The importance of small island populations for the long term survival of endangered large-bodied insular mammals

This study shows that small island populations of anoa and babirusa have higher genetic quality despite lower diversity, suggesting they should be prioritized for conservation over mainland translocations.

Modulation of endogenous opioid signaling by inhibitors of puromycin sensitive aminopeptidase

This paper develops PSA inhibitors to prolong enkephalin stability and reduce pain, showing analgesic effects in vivo and confirming their mechanism through pharmacokinetics and modeling.

Cellular mechanisms underlying beneficial versus detrimental effects of bacterial antitumor immunotherapy

This study investigates how different routes of Listeria monocytogenes administration affect tumor growth in mice, finding that IV followed by IT administration controls tumor growth through anti-Lm CD8 T cells.

Improving the application of Important Plant Areas to conserve threatened habitats: a case study of Uganda

This study evaluates the application of Important Plant Areas (IPAs) in Uganda, finding that current thresholds under Criterion C limit conservation outcomes and recommends adjusting thresholds for better habitat protection.

CyVerse: Cyberinfrastructure for Open Science

The paper describes CyVerse, an open-source cyberinfrastructure platform for life sciences, and outlines a strategic blueprint for managing SaaS and IaC as free and open-source software.

Pathogenic Mutations in the C2A Domain of Dysferlin form Amyloid that Activates the Inflammasome.

This study shows that C2A domain mutations in dysferlin cause amyloid formation, which activates the NLRP3 inflammasome and leads to inflammation and muscle dysfunction in Limb-Girdle Muscular Dystrophy Type-2B/2R.

Upregulated NF-κB pathway proteins may underlie APOE4 associated astrocyte phenotypes in sporadic Alzheimer's disease

This study identifies APOE44-associated astrocyte phenotypes in Alzheimer's disease, linking them to upregulated NF-κB pathway proteins.

Comparative transcriptomics reveal differential gene expression in Plasmodium vivax geographical isolates and implications on erythrocyte invasion mechanisms

This paper compares the transcriptomes of Plasmodium vivax isolates from different geographical regions, identifying differential gene expression patterns and potential biomarkers for gametocyte detection.

Single-cell profiling uncovers a Muc4-expressing metaplastic gastric cell type sustained by Helicobacter pylori-specific inflammation

The paper identifies a Muc4-expressing metaplastic gastric cell type in mice driven by H. pylori inflammation and shows its association with proliferation in human gastric cancer.

Structural and Computational Design of a SARS-CoV-2 Spike Antigen with Increased Receptor Binding Domain Exposure and Improved Immunogenicity

This study designs a modified SARS-CoV-2 Spike antigen with increased RBD exposure and immunogenicity, showing improved neutralizing antibody responses in mice.

Towards modelling cold-water coral reef-scale crumbling: Including morphological variability in mechanical surrogate models

The paper develops mechanical surrogate models to predict reef-crumbling in cold-water corals by accounting for morphological variability and scale-dependent mechanical properties.

A long interval between priming and boosting SARS-CoV-2 mRNA vaccine doses enhances B cell responses with limited impact on T cell immunity

This study shows that a longer interval between SARS-CoV-2 mRNA vaccine doses enhances B cell responses but has minimal impact on T cell immunity.

Pre-neoplastic stromal cells drive BRCA1-mediated breast tumorigenesis

The paper shows pre-neoplastic stromal cells promote BRCA1-driven breast cancer by inducing epithelial proliferation and altering differentiation.

Augmented Transcutaneous Stimulation Using an Injectable Electrode

This paper presents an electroquasistatic model to improve transcutaneous power delivery to an injectable electrode by accounting for capacitive and resistive mechanisms.

Building Back More Equitable STEM Education: Teach Science by Engaging Students in Doing Science

This paper advocates for equitable STEM education through Course-based Undergraduate Research Experiences (CUREs), showing they can improve access and inclusion in science education.

SUN-MKL1 crosstalk regulates nuclear deformation and fast motility of breast carcinoma cells in fibrillar ECM micro-environment

In vivo optical metabolic imaging of long-chain fatty acid uptake in orthotopic models of triple negative breast cancer

This study develops an in vivo optical imaging method to quantify long-chain fatty acid uptake in breast cancer models, showing reduced uptake with MYC downregulation and increased uptake with tumor aggressiveness.

Disruption of Adaptive Immunity Enhances Disease in SARS-CoV-2 Infected Syrian Hamsters

This study shows that disrupting adaptive immunity in Syrian hamsters worsens SARS-CoV-2 disease, but a neutralizing antibody reduces infection even in immunosuppressed animals.

Pseudomonas aeruginosa isolates co-incubated with Acanthamoeba castellanii exhibit phenotypes similar to chronic cystic fibrosis isolates

This paper shows that Pseudomonas aeruginosa co-incubated with Acanthamoeba castellanii develops genetic and phenotypic traits similar to chronic cystic fibrosis isolates, suggesting similar selection pressures from different host environments.

Probing the effect of glycosaminoglycan depletion on integrin interactions with collagen I fibrils in the native ECM environment.

This study investigates how glycosaminoglycan depletion affects integrin 2I domain interactions with collagen I fibrils and their mechanical properties in the ECM.

Canopy parkour: movement ecology of post-hatch dispersal in a gliding nymphal stick insect (Extatosoma tiaratum)

This study investigates the movement ecology of post-hatch dispersal in the gliding stick insect Extatosoma tiaratum, revealing navigation strategies and gliding behavior for canopy access.

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

Overtone focusing in biphonic Tuvan throat singing

This study investigates biphonic Tuvan throat singing, showing how vocal tract morphology modulates overtones to produce two simultaneous pitches through linear filtering.

Increased Dynamics of α-Synuclein Fibrils by β-Synuclein Leads to Reduced Seeding and Cytotoxicity

This study shows that β-synuclein reduces the cytotoxicity and seeding capacity of α-synuclein fibrils by increasing their dynamics without altering their core structure.

How does genome size affect the evolution of pollen tube growth rate, a haploid performance trait?

This study investigates how genome size affects pollen tube growth rates across seed plants, finding negative correlations in gymnosperms and positive effects of neo-polyploidy in angiosperms.

Viral-mediated optogenetic stimulation of peripheral motor nerves in non-human primates

This study demonstrates optogenetic stimulation of peripheral motor nerves in non-human primates using viral constructs, showing functional expression and EMG responses to light.

Chemically-induced Neurite-like Outgrowth Reveals Multicellular Network Function in Patient-derived Glioblastoma Cells

The paper shows that ROCKi promotes neurite-like outgrowth in GBM cells, forming radiation-resistant multicellular networks that can be reversed.

Taking a deeper look: Quantifying the differences in fish assemblages between shallow and mesophotic temperate rocky reefs

This study compares fish assemblages between shallow and mesophotic temperate reefs, finding significant differences driven by specific species and depth-related ecological factors.

Robust and stable transcriptional repression in Giardia using CRISPRi

This study develops CRISPRi for stable transcriptional repression in Giardia, demonstrating efficient gene knockdown and phenotypic effects.