Membrane Tension Integrates Physical and Signaling Cues to Gate Cell Fate Transitions
Gibran Ali, Daniel F. Gibbard, Elisa Ghelfi, Aaron Olson, Junming Cai, Aidan Balagtas, Isaiah Klein, Emily C. Maccoux, Yulong Han, Akihiro Miura, Ming Guo, Ian A. Glass, Munemasa Mori, Douglas Brownfield
This paper identifies cell membrane tension as a regulator of epithelial fate transitions in the lung, showing it integrates physical and signaling cues to control AT1 and AT2 cell differentiation.
bioRxiv · Mar 5, 2026 · PreprintCell Biology