Estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts
Adriana Marques-Carvalho, Gareeballah Osman Adam, Ankita Chalke, Ana Resende-Coelho, Olivia Reyes‐Castro, Aaron Warren, Luís F. Grilo, Claudia C.S. Chini, Benjamin Stronach, Farah Alturkmani, Elena Ambrogini, Eduardo N Chini, Ha‐Neui Kim, Maria Almeida
This study shows estrogens protect bone mass by inhibiting NAD+ metabolism in osteoclasts, reducing bone resorption through suppression of SIRT3 activity.
bioRxiv · Jul 11, 2025 · PreprintMolecular Biology